SNX18 and SOS2

Data Source:
HPRD (in vitro)

		SNX18	SOS2
Description		sorting nexin 18	SOS Ras/Rho guanine nucleotide exchange factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle Extracellular Exosome	Cytosol
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Mitotic Cytokinesis Endocytosis Protein Transport Endosomal Transport Cleavage Furrow Formation Positive Regulation Of GTPase Activity	B Cell Homeostasis G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of T Cell Differentiation In Thymus Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Pro-B Cell Differentiation
Pathways		Clathrin-mediated endocytosis	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Activation of RAC1 Interleukin-15 signaling
Drugs
Diseases
GWAS		Immune response to smallpox vaccine (IL-6) ( 22542470)	Birth weight ( 31043758) Erythema nodosum in inflammatory bowel disease ( 24487271) Estimated glomerular filtration rate ( 31015462) Hemoglobin ( 32888494) Intraocular pressure ( 29617998 29785010 31959993 30054594) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Periodontal disease-related phenotype (Socransky) ( 24347629) Pulse pressure ( 30578418) Red blood cell count ( 32888494)
Interacting Genes		19 interacting genes: ABI2 CPSF7 CYSRT1 DPPA4 GABARAP GOLGA2 HSF2BP HSPB2 HSPB2-C11orf52 KHDRBS3 KRTAP1-1 KRTAP6-3 MAP1LC3B MDFI MSS51 PTPN21 SOS1 SOS2 ZBTB42	16 interacting genes: ABI1 ABL1 BIN1 CD2AP CRKL EGFR GRAP2 GRB2 HRAS ITSN2 PACSIN3 PLCG1 SH3D19 SHC1 SNX18 SNX9
Entrez ID		112574	6655
HPRD ID		15407	03149
Ensembl ID		ENSG00000178996	ENSG00000100485
Uniprot IDs		Q96RF0	Q07890
PDB IDs			6EIE
Enriched GO Terms of Interacting Partners?
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