DDX20 and DHX9

Data Source:
HPRD (in vivo, in vitro)

		DDX20	DHX9
Description		DEAD-box helicase 20	DExH-box helicase 9
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Membrane SMN Complex SMN-Sm Protein Complex Gemini Of Coiled Bodies	Intracellular Anatomical Structure Nucleus Nucleoplasm Perichromatin Fibrils Nucleolus Cytoplasm Centrosome Cytosol Polysome Actin Cytoskeleton Membrane RISC Complex Nuclear Body Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule Polysomal Ribosome RISC-loading Complex CRD-mediated MRNA Stability Complex Nuclear Stress Granule Ribonucleoprotein Complex
	Molecular Function	DNA Binding RNA Binding RNA Helicase Activity Protein Binding ATP Binding Repressing Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding Regulatory Region RNA Binding RNA Polymerase II Transcription Factor Binding DNA Binding DNA Helicase Activity DNA Replication Origin Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding ATP Binding ATPase Activity Nucleoside-triphosphatase Activity Chromatin DNA Binding 3'-5' DNA/RNA Helicase Activity 3'-5' RNA Helicase Activity SiRNA Binding RNA Stem-loop Binding 3'-5' DNA Helicase Activity Triplex DNA Binding Metal Ion Binding Nucleoside-triphosphate Diphosphatase Activity Importin-alpha Family Protein Binding RNA Polymerase Binding RISC Complex Binding Polysome Binding Single-stranded 3'-5' DNA Helicase Activity Sequence-specific MRNA Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Spliceosomal Tri-snRNP Complex Assembly Spliceosomal SnRNP Assembly RNA Processing Positive Regulation Of Apoptotic Process Import Into Nucleus	Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Osteoblast Differentiation DNA Replication DNA-templated Transcription, Termination Regulation Of Transcription By RNA Polymerase II Inflammatory Response RNA Secondary Structure Unwinding Targeting Of MRNA For Destruction Involved In RNA Interference Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-18 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Cellular Protein-containing Complex Assembly DNA-templated Viral Transcription G-quadruplex DNA Unwinding Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of DNA Repair Positive Regulation Of DNA Replication Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Export From Nucleus Positive Regulation Of Fibroblast Proliferation Rhythmic Process Positive Regulation Of Viral Transcription Regulation Of MRNA Processing Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response MRNA Transport Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Response To Cytokine Stimulus Pyroptosis Small RNA Loading Onto RISC CRD-mediated MRNA Stabilization Cellular Response To Tumor Necrosis Factor Cellular Response To Exogenous DsRNA Protein Localization To Cytoplasmic Stress Granule Positive Regulation Of Viral Translation Positive Regulation Of Polysome Binding Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Gene Silencing By MiRNA Regulation Of Cytoplasmic Translation Positive Regulation Of Cytoplasmic Translation
Pathways		snRNP Assembly	RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Body mass index ( 29273807) Metabolite levels ( 23823483) Venous thromboembolism ( 32232851)
Interacting Genes		32 interacting genes: AGO2 APP CRYAB DHX9 ETV3 GEMIN2 GEMIN4 GEMIN5 HDAC2 HDAC5 NCOR1 NCOR2 NR0B2 NUFIP1 PRRC2A RN7SL1 RNU1-1 RNU2-1 SIN3A SMN1 SMN2 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SNUPN STXBP2 STXBP3 TP53	43 interacting genes: ACTA1 AKAP8L APBB1 BRCA1 DDX20 DDX5 DUX4 EIF2AK2 ESR1 GEMIN2 GEMIN4 GTF2B H2AX HDLBP HNRNPC HNRNPK IL7R ILF3 JUN KHDRBS1 LINC01554 MBD2 NXF1 OGA PCNA POLR2A PRMT1 PRPF40A PRPF8 PTEN RBM4 RELA SMN1 SMN2 SNRPB SNRPB2 SRPK1 SSRP1 STAU1 TBP TOP2A UBE2I YWHAQ
Entrez ID		11218	1660
HPRD ID		05859	04386
Ensembl ID		ENSG00000064703	ENSG00000135829
Uniprot IDs		Q9H4N4 Q9UHI6	B3KU66 Q08211
PDB IDs		2OXC 3B7G	3LLM 3VYX 3VYY
Enriched GO Terms of Interacting Partners?
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