USP39 and SAE1

Data Source:
BioGRID (enzymatic study)

		USP39	SAE1
Description		ubiquitin specific peptidase 39	SUMO1 activating enzyme subunit 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U4/U6 X U5 Tri-snRNP Complex	Nucleus Nucleoplasm Cytoplasm SUMO Activating Enzyme Complex
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding	Ubiquitin Activating Enzyme Activity Protein Binding Protein C-terminus Binding Enzyme Activator Activity SUMO Activating Enzyme Activity ATP-dependent Protein Binding Small Protein Activating Enzyme Binding Protein Heterodimerization Activity
	Biological Process	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing Cell Cycle RNA Splicing Protein Deubiquitination Protein Phosphopantetheinylation Cell Division	Protein Ubiquitination Protein Sumoylation Protein Phosphopantetheinylation Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Sumoylation Regulation Of Catalytic Activity Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		mRNA Splicing - Major Pathway	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs
Diseases
GWAS		Neurofibrillary tangles ( 31497858)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Multiple sclerosis ( 31604244 21833088) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 32888494) White blood cell count ( 32888494 27863252)
Interacting Genes		14 interacting genes: ACVR1 APP CHEK2 LRRK2 SAE1 SP1 SRPK1 SRPK2 TRAF6 TRIM25 TRIM26 TRIM39 TRIM5 TRIM8	22 interacting genes: AGTR1 APP CRX ERCC6 ETV4 HSPA1A HSPA2 IL3RA MEOX2 NFYC PAX5 PAX6 PAX8 PTK2 SUMO1 SUMO2 SUMO3 UBA2 UBD UBE2E3 UBE2I USP39
Entrez ID		10713	10055
HPRD ID		07165	18010
Ensembl ID		ENSG00000168883	ENSG00000142230
Uniprot IDs		A0A087X1B2 B3KMG1 B3KPG7 B7Z7L9 Q53GS9	A0A024R0R4 Q9UBE0
PDB IDs		3JCR 6AH0 6QW6 6QX9	1Y8Q 1Y8R 3KYC 3KYD 6CWY 6CWZ
Enriched GO Terms of Interacting Partners?
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