PLAAT3 and MARK2

Data Source:
BioGRID (affinity chromatography technology)

		PLAAT3	MARK2
Description		phospholipase A and acyltransferase 3	microtubule affinity regulating kinase 2
Image
GO Annotations	Cellular Component	Cellular_component Cytoplasm Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Mitochondrion Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Microtubule Bundle
	Molecular Function	Phospholipase A2 Activity Protein Binding Phospholipase A1 Activity N-acyltransferase Activity Phosphatidylserine 1-acylhydrolase Activity 1-acyl-2-lysophosphatidylserine Acylhydrolase Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	Magnesium Ion Binding RNA Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Protein Kinase Activator Activity Cadherin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Triglyceride Metabolic Process Phospholipid Metabolic Process Peroxisome Organization Phospholipid Biosynthetic Process Response To Bacterium Viral Process Lipid Catabolic Process Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Negative Regulation Of Cell Cycle Ether Lipid Metabolic Process N-acylphosphatidylethanolamine Metabolic Process Regulation Of Adipose Tissue Development	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Establishment Of Cell Polarity Activation Of Protein Kinase Activity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Microtubule Binding
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI
Drugs			Fostamatinib
Diseases
GWAS			anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132)
Interacting Genes		4 interacting genes: PPP2R1A UBQLN1 UBQLN2 UBQLN4	32 interacting genes: BAIAP2 CAMK1 CASK DVL3 FBXO7 GAB1 GSK3B HDAC7 KIF13B KIFAP3 MAP3K3 MAPT MTCL1 NEDD4 NEDD4L PARD3B PARD6A PINK1 PKD1 PRKCE PTPRD RAB11FIP2 RNF41 RPA2 SMURF1 STK11 STK3 STK4 UTRN YWHAB YWHAQ YWHAZ
Entrez ID		11145	2011
HPRD ID		13671	02753
Ensembl ID		ENSG00000176485	ENSG00000072518
Uniprot IDs		A0A024R561 P53816	A0A140VJP1 A8K2S4 Q7KZI7
PDB IDs		2KYT 4DOT 4FA0 4Q95	3IEC 5EAK 5KZ7 5KZ8
Enriched GO Terms of Interacting Partners?
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