PKIG and DYNLL1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vivo)

		PKIG	DYNLL1
Description		cAMP-dependent protein kinase inhibitor gamma	dynein light chain LC8-type 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Kinetochore Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane Cilium COP9 Signalosome Membrane Dynein Complex Tertiary Granule Membrane Mitotic Spindle Ciliary Tip Ficolin-1-rich Granule Membrane Axon Cytoplasm
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding	Motor Activity Enzyme Inhibitor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Nitric-oxide Synthase Regulator Activity Identical Protein Binding Protein-containing Complex Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding Scaffold Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of CAMP-dependent Protein Kinase Activity	G2/M Transition Of Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Apoptotic Process Spermatid Development Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Macroautophagy Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Substantia Nigra Development Intraciliary Retrograde Transport Intraciliary Transport Involved In Cilium Assembly Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Neutrophil Degranulation Motile Cilium Assembly Negative Regulation Of Nitric Oxide Biosynthetic Process Cilium Assembly Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Non-motile Cilium Assembly Positive Regulation Of ATP-dependent Microtubule Motor Activity, Plus-end-directed
Pathways			Activation of BIM and translocation to mitochondria Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Macroautophagy MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Inflammatory bowel disease ( 28067908) Pancreatic cancer ( 29422604) Ulcerative colitis ( 28067908)	High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		3 interacting genes: DYNLL1 DYNLL2 MEOX2	107 interacting genes: ACTB ACTC1 ACTG1 ALDOA AMOTL2 B3GALT4 BCAS1 BCL2L11 BMF C12orf40 C14orf119 C19orf44 CA2 CACNB1 CCDC28A CLIP2 CS DAZ1 DCTN5 DLG4 DLGAP1 DNAJB9 DNAL4 DNM2 DNM3 DNMT1 DPPA3 DYNC1H1 DYNC1I1 EEF1A1 ERG28 FAM117B FAM153A FAM53B GABARAPL1 GABARAPL2 GAPDH GLUD1 GLUL GNL3L GPHN GPRIN2 GRIN3A HIP1R HMBOX1 HOMER3 HSPA8 IHO1 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MORN3 MRE11 MTA1 MTR MYO10 MYO5A NDEL1 NDUFA4L2 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 ODF3 OR7C2 OTUD6A PAK1 PAN2 PARD3 PAX6 PCM1 PFKM PFKP PKIA PKIB PKIG POLH PPP3R2 RAB4A RACK1 RASGRP4 RGS2 SHROOM3 SLC13A1 SMCP TERT THAP10 THAP8 TNFRSF14 TP53BP1 TRIM54 TSNARE1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A ZNF710
Entrez ID		11142	8655
HPRD ID		05379	03334
Ensembl ID		ENSG00000168734	ENSG00000088986
Uniprot IDs		Q549H9 Q9Y2B9	P63167 Q6FGH9
PDB IDs			1CMI 3ZKE 3ZKF 6GZJ 6GZL 6RLB 6SC2
Enriched GO Terms of Interacting Partners?
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