CIT and RHOB

Data Source:
BioGRID (far western blotting, two hybrid)

		CIT	RHOB
Description		citron rho-interacting serine/threonine kinase	ras homolog family member B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Membrane	Nucleus Early Endosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Endosome Membrane Cytoplasmic Vesicle Late Endosome Membrane Cleavage Furrow Cell Projection Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Transcription Coactivator Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding SH3 Domain Binding Protein Kinase Binding PDZ Domain Binding Protein Serine/threonine Kinase Inhibitor Activity Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Kinase Binding
	Biological Process	Mitotic Cell Cycle Mitotic Cytokinesis Peptidyl-threonine Phosphorylation Actomyosin Structure Organization Positive Regulation Of Cytokinesis Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Generation Of Neurons Neuron Apoptotic Process Negative Regulation Of Protein Serine/threonine Kinase Activity	Mitotic Cytokinesis Angiogenesis Intracellular Protein Transport Apoptotic Process Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Endosome To Lysosome Transport Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Cell Migration Cell Differentiation Regulation Of Cell Migration Negative Regulation Of Cell Migration Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Cell Cycle Regulation Of Small GTPase Mediated Signal Transduction Endothelial Tube Morphogenesis Cellular Response To Hydrogen Peroxide Cellular Response To Ionizing Radiation
Pathways		RHO GTPases activate CIT RHO GTPases activate CIT	GPVI-mediated activation cascade Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHO GTPases Activate Formins RHO GTPases Activate Rhotekin and Rhophilins
Drugs		Fostamatinib	Botulinum toxin type A
Diseases
GWAS		Number of sexual partners ( 30643258) Urgency urinary incontinence ( 25524241)	Systemic sclerosis ( 21750679) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		10 interacting genes: DISC1 DLG4 GRIN1 GRIN2D MTNR1A RAC1 RHOA RHOB RHOC RND3	12 interacting genes: ARHGDIG ARHGEF3 CIT FNTA MAP1A NEDD4L PDE6D PGGT1B PPP2CA RHPN2 SMURF1 TNFAIP1
Entrez ID		11113	388
HPRD ID		09289	01321
Ensembl ID		ENSG00000122966	ENSG00000143878
Uniprot IDs		O14578	P62745
PDB IDs			2FV8 6HXU 6SGE
Enriched GO Terms of Interacting Partners?
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