DNAJB4 and TBL1X

Data Source:
BioGRID (two hybrid)

		DNAJB4	TBL1X
Description		DnaJ heat shock protein family (Hsp40) member B4	transducin beta like 1 X-linked
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Repressor Complex Mitotic Spindle
	Molecular Function	ATPase Activator Activity Protein Binding Unfolded Protein Binding Chaperone Binding	Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Transcription Factor Binding Protein Domain Specific Binding Histone Binding
	Biological Process	Response To Unfolded Protein Response To Heat Positive Regulation Of ATPase Activity Chaperone Cofactor-dependent Protein Refolding	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Proteolysis Sensory Perception Of Sound Histone Deacetylation Regulation Of Lipid Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cutaneous melanoma or hair colour ( 32341527) Diastolic blood pressure ( 30224653) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Waist circumference ( 25673412)	Prostate cancer ( 23535732) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: HSPA6 MDM2 OPRM1 PABPN1 POLR1D RUVBL2 SDIM1 SMAD3 TBL1X TBPL2	29 interacting genes: ARL3 CDC34 CORO2A CTNNB1 DLX3 DNAJB4 FOXK2 GPS2 H2AC18 H2BC21 H3C14 H4C1 H4C14 HDAC3 HP HR KHDRBS1 MECP2 NCOR1 NCOR2 SKP1 TAB2 TBL1XR1 TERF1 THRA THRB TINF2 UBE2D1 UBE2I
Entrez ID		11080	6907
HPRD ID		07486	02183
Ensembl ID		ENSG00000162616	ENSG00000101849
Uniprot IDs		B4DNN2 Q9UDY4	A0A024RBV9 O60907
PDB IDs			2XTC 2XTD 2XTE
Enriched GO Terms of Interacting Partners?
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