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HELQ and RIPK3
Data Source:
BioGRID
(pull down)
HELQ
RIPK3
Description
helicase, POLQ like
receptor interacting serine/threonine kinase 3
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleus
Cytoplasm
Cytosol
Protein-containing Complex
Molecular Function
DNA Binding
Protein Binding
ATP Binding
Single-stranded 3'-5' DNA Helicase Activity
Transcription Coactivator Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
NF-kappaB-inducing Kinase Activity
Protein Binding
ATP Binding
Identical Protein Binding
Protein-containing Complex Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Double-strand Break Repair Via Homologous Recombination
RRNA Processing
DNA Duplex Unwinding
Regulation Of T Cell Mediated Cytotoxicity
Regulation Of Adaptive Immune Response
Cellular Protein Modification Process
Signal Transduction
I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Phosphatase Activity
Activation Of Protein Kinase Activity
Regulation Of Interferon-gamma Production
T Cell Differentiation In Thymus
NIK/NF-kappaB Signaling
Regulation Of Apoptotic Process
T Cell Homeostasis
Positive Regulation Of Transcription, DNA-templated
Regulation Of Activated T Cell Proliferation
Protein Autophosphorylation
Lymph Node Development
Spleen Development
Thymus Development
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Ligase Activity
Positive Regulation Of Oxidoreductase Activity
Defense Response To Virus
Positive Regulation Of Necroptotic Process
Regulation Of Activation-induced Cell Death Of T Cells
Necroptotic Process
Cellular Response To Hydrogen Peroxide
Apoptotic Signaling Pathway
Programmed Necrotic Cell Death
Necroptotic Signaling Pathway
Execution Phase Of Necroptosis
Amyloid Fibril Formation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
TRIF-mediated programmed cell death
TRP channels
RIPK1-mediated regulated necrosis
Regulation of necroptotic cell death
TLR3-mediated TICAM1-dependent programmed cell death
IKK complex recruitment mediated by RIP1
Microbial modulation of RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS
Age-related cognitive decline (executive function) (slope of z-scores) (
30954325
)
Breast cancer (
29059683
)
Menopause (age at onset) (
22267201
26414677
29773799
)
Diastolic blood pressure (
27841878
)
Heel bone mineral density (
30598549
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Interacting Genes
1 interacting genes:
RIPK3
22 interacting genes:
BIRC2
BIRC3
BUB1B
DAXX
GBE1
H1-5
HELQ
HSPBAP1
IL24
NME8
PELI1
RFX6
RIPK1
SRPK2
TICAM1
TLE6
TMEM44
TNFRSF1A
TRAF2
UTP11
XIAP
ZSCAN20
Entrez ID
113510
11035
HPRD ID
08422
09315
Ensembl ID
ENSG00000163312
ENSG00000129465
Uniprot IDs
Q8TDG4
Q9Y572
PDB IDs
5V7Z
5ZCK
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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