SLC27A4 and EPS8

Data Source:
BioGRID (two hybrid)

		SLC27A4	EPS8
Description		solute carrier family 27 member 4	epidermal growth factor receptor pathway substrate 8
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Microvillus Membrane Integral Component Of Membrane Brush Border Membrane	Plasma Membrane Cell Cortex Growth Cone Vesicle Stereocilium Ruffle Membrane Synapse Extracellular Exosome
	Molecular Function	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty Acid Transporter Activity Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity Palmitoyl-CoA Ligase Activity Oleoyl-CoA Ligase Activity	Actin Binding Protein Binding Small GTPase Binding Signaling Adaptor Activity
	Biological Process	Medium-chain Fatty Acid Transport Long-chain Fatty Acid Metabolic Process Fatty Acid Metabolic Process Response To Nutrient Fatty Acid Transport Long-chain Fatty Acid Transport Very Long-chain Fatty Acid Catabolic Process Positive Regulation Of Apoptotic Process Skin Development Glucose Import In Response To Insulin Stimulus Long-chain Fatty Acid Import Into Cell Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of All-trans-retinyl-ester Hydrolase, 11-cis Retinol Forming Activity Activation Of GTPase Activity Transport Across Blood-brain Barrier Lipid Transport Across Blood-brain Barrier	Rho Protein Signal Transduction Regulation Of Cell Shape Exit From Mitosis Rac Protein Signal Transduction Regulation Of Actin Filament Length Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Regulation Of Catalytic Activity Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility Positive Regulation Of Ruffle Assembly
Pathways		Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) Transport of fatty acids
Drugs
Diseases		Ichthyosis prematurity syndrome
GWAS		Body mass index ( 26426971)	Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913)
Interacting Genes		2 interacting genes: EPS8 TENT5B	61 interacting genes: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BORCS6 BYSL C19orf25 C6orf141 C8orf33 CASK CBL CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 ITSN2 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RCAN3 RFXAP RSPH14 RUNX1T1 SCRN3 SERPINA5 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XAGE2 XRCC6 ZZZ3
Entrez ID		10999	2059
HPRD ID		09172	02563
Ensembl ID		ENSG00000167114	ENSG00000151491
Uniprot IDs		A0A024R8D2 Q6P1M0	B4E3T6 Q12929
PDB IDs			2E8M
Enriched GO Terms of Interacting Partners?
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