STIP1 and ACD

Data Source:
BioGRID (two hybrid)

		STIP1	ACD
Description		stress induced phosphoprotein 1	ACD shelterin complex subunit and telomerase recruitment factor
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GO Annotations	Cellular Component	Nucleus Golgi Apparatus Cytosol Protein-containing Complex Chaperone Complex	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleoplasm Telomerase Holoenzyme Complex Nuclear Body Shelterin Complex
	Molecular Function	RNA Binding Protein Binding Protein C-terminus Binding Hsp70 Protein Binding Chaperone Binding Hsp90 Protein Binding	Protein Binding Telomeric DNA Binding Protein-containing Complex Binding DNA Polymerase Binding
	Biological Process	Cellular Response To Interleukin-7	Telomere Maintenance Intracellular Protein Transport Telomere Maintenance Via Telomerase Telomere Capping Protection From Non-homologous End Joining At Telomere Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomerase Activity Positive Regulation Of Single-stranded Telomeric DNA Binding Protein Localization To Chromosome, Telomeric Region Establishment Of Protein Localization To Telomere
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR)	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs		Copper
Diseases
GWAS		Attention deficit hyperactivity disorder ( 21784300) Crohn's disease ( 28067908) Fruit consumption ( 32066663)	Hemoglobin levels ( 32327693) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		23 interacting genes: ACD ACVR1 AIP APP CDC37 CLCN1 CLK1 EGFR ERBB2 FKBP4 FKBP5 HSP90AA1 HSPA14 HSPA1A HSPA1B HSPA8 LMO2 MAP3K8 POT1 PRNP PTGES3 SUMO2 SUMO4	63 interacting genes: ACTB ADPRH AFAP1L2 AIPL1 ANKMY2 ANXA8L1 APOBEC3F BAG3 CKB CTTN DBN1 DBNL DCX DPYSL3 EIF3G EIF4B ENO2 ENSA FAM131B FKBP6 GAPDH HSP90AB1 IPO5 IVL LASP1 LDHA LGALSL LLGL1 LRRC25 NCDN NTAQ1 NUDC NUDCD2 PAGE2 PDLIM2 PEX5 PFKP PGM2 POT1 RBKS RECQL4 RGS3 RPSA SBDS STIP1 STUB1 SULT1C2 TAGLN TBC1D10A TBCD TINF2 TOMM34 TRIM15 TRIM16 TRIM55 TRIM63 TUBB2A TUBB4B USP7 XRCC6 YWHAE ZFP36L1 ZNF790
Entrez ID		10963	65057
HPRD ID		05454	12417
Ensembl ID		ENSG00000168439	ENSG00000102977
Uniprot IDs		P31948 V9HW72	A0A590TQL1 Q96AP0
PDB IDs		1ELR 1ELW 2LNI 2NC9 3ESK 3FWV	2I46 5H65 5I2X 5I2Y 5UN7 5XYF
Enriched GO Terms of Interacting Partners?
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