POP1 and PYCARD

Data Source:
HPRD (in vivo)

		POP1	PYCARD
Description		POP1 homolog, ribonuclease P/MRP subunit	PYD and CARD domain containing
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GO Annotations	Cellular Component	Ribonuclease MRP Complex Extracellular Space Nucleoplasm Nucleolar Ribonuclease P Complex Nucleolus Multimeric Ribonuclease P Complex	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol IkappaB Kinase Complex Protein-containing Complex Secretory Granule Lumen Azurophil Granule Lumen Neuronal Cell Body NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex
	Molecular Function	RNA Binding Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding	Protease Binding Interleukin-6 Receptor Binding Protein Binding Tropomyosin Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Myosin I Binding Enzyme Binding Pyrin Domain Binding Identical Protein Binding Protein Homodimerization Activity Ion Channel Binding Protein Dimerization Activity BMP Receptor Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
	Biological Process	TRNA 5'-leader Removal TRNA Processing TRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Myeloid Dendritic Cell Activation Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Myeloid Dendritic Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Adaptive Immune Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Signal Transduction Regulation Of Autophagy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Regulation Of Protein Stability Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-beta Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neutrophil Degranulation Macropinocytosis Innate Immune Response Positive Regulation Of JNK Cascade Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Positive Regulation Of T Cell Activation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Defense Response To Virus Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Protein Serine/threonine Kinase Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Release Of Cytochrome C From Mitochondria Activation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of T Cell Migration Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		tRNA processing in the nucleus	CLEC7A/inflammasome pathway Neutrophil degranulation The NLRP3 inflammasome The AIM2 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases
GWAS			Post bronchodilator FEV1 ( 26634245)
Interacting Genes		8 interacting genes: POP4 POP5 PTEN PYCARD RPP25 RPP30 RPP38 RPP40	12 interacting genes: CASP1 EXOC5 MEFV NLRC4 NLRP1 NLRP12 NLRP3 POP1 PRKAR1A PYDC2 SRF USP50
Entrez ID		10940	29108
HPRD ID		03923	06020
Ensembl ID		ENSG00000104356	ENSG00000103490
Uniprot IDs		Q96F88 Q99575	Q9ULZ3
PDB IDs		6AHR 6AHU	1UCP 2KN6 3J63 5H8O 6K99 6KI0 6N1H
Enriched GO Terms of Interacting Partners?
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