PYCARD and USP50

Data Source:
BioGRID (enzymatic study)

		PYCARD	USP50
Description		PYD and CARD domain containing	ubiquitin specific peptidase 50
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol IkappaB Kinase Complex Protein-containing Complex Secretory Granule Lumen Azurophil Granule Lumen Neuronal Cell Body NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex	Cytosol Postsynaptic Density Extrinsic Component Of Plasma Membrane Midbody Extrinsic Component Of Endosome Membrane Dendritic Spine
	Molecular Function	Protease Binding Interleukin-6 Receptor Binding Protein Binding Tropomyosin Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Myosin I Binding Enzyme Binding Pyrin Domain Binding Identical Protein Binding Protein Homodimerization Activity Ion Channel Binding Protein Dimerization Activity BMP Receptor Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Thiol-dependent Ubiquitin-specific Protease Activity Ubiquitin-like Protein-specific Protease Activity
	Biological Process	Myeloid Dendritic Cell Activation Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Myeloid Dendritic Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Adaptive Immune Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Signal Transduction Regulation Of Autophagy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Regulation Of Protein Stability Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-beta Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neutrophil Degranulation Macropinocytosis Innate Immune Response Positive Regulation Of JNK Cascade Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Positive Regulation Of T Cell Activation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Defense Response To Virus Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Protein Serine/threonine Kinase Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Release Of Cytochrome C From Mitochondria Activation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of T Cell Migration Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Endosome Organization Ras Protein Signal Transduction Protein Deubiquitination Protein Phosphopantetheinylation Positive Regulation Of Interleukin-1 Beta Production Nuclear Speck Organization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Cysteine-type Endopeptidase Activity
Pathways		CLEC7A/inflammasome pathway Neutrophil degranulation The NLRP3 inflammasome The AIM2 inflammasome Purinergic signaling in leishmaniasis infection
Drugs
Diseases
GWAS		Post bronchodilator FEV1 ( 26634245)	Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Myeloid white cell count ( 27863252) QT interval ( 24952745) Refractive error ( 32231278) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)
Interacting Genes		12 interacting genes: CASP1 EXOC5 MEFV NLRC4 NLRP1 NLRP12 NLRP3 POP1 PRKAR1A PYDC2 SRF USP50	3 interacting genes: HSP90AA1 HSP90AB1 PYCARD
Entrez ID		29108	373509
HPRD ID		06020	15639
Ensembl ID		ENSG00000103490	ENSG00000170236
Uniprot IDs		Q9ULZ3	Q70EL3
PDB IDs		1UCP 2KN6 3J63 5H8O 6K99 6KI0 6N1H
Enriched GO Terms of Interacting Partners?
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