EDAR and MAP3K14

Data Source:
HPRD (in vivo)

		EDAR	MAP3K14
Description		ectodysplasin A receptor	mitogen-activated protein kinase kinase kinase 14
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Apical Part Of Cell	Fibrillar Center Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity
	Biological Process	Hair Follicle Development Apoptotic Process Epidermis Development Positive Regulation Of Gene Expression Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Odontogenesis Of Dentin-containing Tooth Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pigmentation Positive Regulation Of JNK Cascade Salivary Gland Cavitation Positive Regulation Of NIK/NF-kappaB Signaling	MAPK Cascade Activation Of MAPKK Activity Protein Phosphorylation Immune Response I-kappaB Kinase/NF-kappaB Signaling Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Defense Response To Virus Cellular Response To Mechanical Stimulus
Pathways		TNFs bind their physiological receptors	CD28 dependent PI3K/Akt signaling Dectin-1 mediated noncanonical NF-kB signaling TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases		Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic
GWAS		Beard thickness ( 26926045) Blood protein levels ( 30072576 29875488 28240269) Cleft lip with or without cleft palate (maternal periconceptional alcohol intake interaction) ( 29535761) Ear morphology ( 26105758) Ear protrusion ( 26105758) Eyebrow thickness ( 30248107) Helix rolling ( 26105758) Lobe attachment ( 26105758) Lobe attachment (rater scored) ( 29198719) Lobe size ( 26105758) lower facial morphology traits (quantitative measurement) ( 27193062) Lung function (FVC) ( 30061609) Male-pattern baldness ( 27182965) Monobrow ( 27182965) Monobrow thickness ( 26926045) Scalp hair shape ( 26926045) Straight vs curly hair ( 27487801 29895819) Thick vs thin eyebrows ( 29895819) Urinary albumin-to-creatinine ratio ( 32600054)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 31959851 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Cognitive function ( 28093568) Joint damage in rheumatoid arthritis ( 26498133) Male-pattern baldness ( 28196072) Multiple sclerosis ( 31604244 21833088) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Plateletcrit ( 32888494)
Interacting Genes		8 interacting genes: EDA EDARADD MAP3K14 SGTA TRAF1 TRAF2 TRAF3 UPK1B	42 interacting genes: ALPL BIRC3 BRCA1 CASP8 CDC37 CHUK EDAR EEF1A1 EGFR ELP1 FBL GRB10 GRB14 GRB7 HSP90AA1 HSP90AB1 IKBKB IKBKG MAP2K4 MAP3K7 MAP3K8 MAPK3 NFKB2 NFKBIA PEBP1 PELI3 RIPK1 RPL30 RPL4 RPL5 RPL6 RPS11 RPS13 SLC9A1 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIM55 TRIM63 ZFP91
Entrez ID		10913	9020
HPRD ID		04974	05230
Ensembl ID		ENSG00000135960	ENSG00000006062
Uniprot IDs		Q9UNE0	Q68D39 Q99558
PDB IDs			4DN5 4G3D 4IDT 4IDV 6WPP 6Z1Q 6Z1T
Enriched GO Terms of Interacting Partners?
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