MAP3K14 and ZFP91

Data Source:
BioGRID (enzymatic study)

		MAP3K14	ZFP91
Description		mitogen-activated protein kinase kinase kinase 14	ZFP91 zinc finger protein, atypical E3 ubiquitin ligase
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity	Ubiquitin-protein Transferase Activity Metal Ion Binding
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Protein Phosphorylation Immune Response I-kappaB Kinase/NF-kappaB Signaling Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Defense Response To Virus Cellular Response To Mechanical Stimulus	Regulation Of Transcription By RNA Polymerase II Activation Of NF-kappaB-inducing Kinase Activity Protein K63-linked Ubiquitination
Pathways		CD28 dependent PI3K/Akt signaling Dectin-1 mediated noncanonical NF-kB signaling TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 31959851 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Cognitive function ( 28093568) Joint damage in rheumatoid arthritis ( 26498133) Male-pattern baldness ( 28196072) Multiple sclerosis ( 31604244 21833088) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Plateletcrit ( 32888494)	Chronotype ( 30696823) HDL cholesterol levels ( 32203549) Medication use (calcium channel blockers) ( 31015401) Morning person ( 30696823) Systolic blood pressure ( 30578418) Ulcerative colitis ( 28067908)
Interacting Genes		42 interacting genes: ALPL BIRC3 BRCA1 CASP8 CDC37 CHUK EDAR EEF1A1 EGFR ELP1 FBL GRB10 GRB14 GRB7 HSP90AA1 HSP90AB1 IKBKB IKBKG MAP2K4 MAP3K7 MAP3K8 MAPK3 NFKB2 NFKBIA PEBP1 PELI3 RIPK1 RPL30 RPL4 RPL5 RPL6 RPS11 RPS13 SLC9A1 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIM55 TRIM63 ZFP91	12 interacting genes: CDKN2A CEP70 CRBN FAM9A MAP3K14 PICK1 POU6F2 SRPK2 TP53BP2 TSPYL2 ZFP41 ZNF526
Entrez ID		9020	80829
HPRD ID		05230	11700
Ensembl ID		ENSG00000006062	ENSG00000186660
Uniprot IDs		Q68D39 Q99558	A0A024R4Z1 A0A024R4Z4 Q96JP5
PDB IDs		4DN5 4G3D 4IDT 4IDV 6WPP 6Z1Q 6Z1T	2M9A
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?