TRAFD1 and ESPL1

Data Source:
BioGRID (proximity labelling technology)

		TRAFD1	ESPL1
Description		TRAF-type zinc finger domain containing 1	extra spindle pole bodies like 1, separase
Image			No pdb structure
GO Annotations	Cellular Component		Nucleus Cytoplasm Centrosome Cytosol Mitotic Spindle
	Molecular Function	Protein Binding Metal Ion Binding	Catalytic Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process	Negative Regulation Of Innate Immune Response	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Mitotic Cytokinesis Proteolysis Apoptotic Process Establishment Of Mitotic Spindle Localization Homologous Chromosome Segregation Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Sister Chromatid Cohesion Meiotic Chromosome Separation
Pathways			Separation of Sister Chromatids
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 30718733) Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence symptom count ( 29460428) Aspartate aminotransferase levels ( 30718733) Body mass index ( 26426971 25673413) Coffee consumption ( 29367735) Hemoglobin ( 19862010) Hemoglobin levels ( 32327693) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Primary biliary cholangitis ( 26394269) Response to alcohol consumption (flushing response) ( 29460428) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 17554300) White blood cell count ( 32888494)	Femoral neck bone mineral density ( 29499414) Lumbar spine bone mineral density ( 29499414)
Interacting Genes		4 interacting genes: HTT NGLY1 TRAF6 UBC	7 interacting genes: MTNR1B PJA1 RFFL TRIM55 TRIM63 USP21 USP28
Entrez ID		10906	9700
HPRD ID		10994	06825
Ensembl ID		ENSG00000135148	ENSG00000135476
Uniprot IDs		A0A024RBK4 O14545	Q14674
PDB IDs		2D9K
Enriched GO Terms of Interacting Partners?
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