WDR3 and PDE10A

Data Source:
HPRD (two hybrid)

		WDR3	PDE10A
Description		WD repeat domain 3	phosphodiesterase 10A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Nuclear Membrane Small-subunit Processome Pwp2p-containing Subcomplex Of 90S Preribosome	Cytosol
	Molecular Function	RNA Binding SnoRNA Binding	3',5'-cyclic-nucleotide Phosphodiesterase Activity CGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity CAMP Binding CGMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	RRNA Processing Maturation Of SSU-rRNA	CAMP Catabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Negative Regulation Of CGMP-mediated Signaling CGMP Catabolic Process
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	cGMP effects G alpha (s) signalling events
Drugs			Caffeine Dipyridamole Papaverine 4,5-bis(4-methoxyphenyl)-2-thiophen-2-yl-1H-imidazole 2-({4-[4-(pyridin-4-ylmethyl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline 2-{[4-(4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy]methyl}quinoline Mardepodect 6,7-DIMETHOXY-4-[(3R)-3-(2-NAPHTHYLOXY)PYRROLIDIN-1-YL]QUINAZOLINE PQ-10 Tofisopam Triflusal Trapidil
Diseases
GWAS			Age-related nuclear cataracts ( 24951543) Autoimmune thyroid disease ( 32581359) Birth weight ( 31043758) Body mass index ( 28552196) Body size at age 10 ( 32376654) Chronotype ( 30696823) Conduct disorder (symptom count) ( 20585324) Cortisol levels (saliva) ( 28843169) Diastolic blood pressure ( 28135244 27841878) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hyperthyroidism ( 30367059) Hypothyroidism ( 30367059 27182965) Inhibitory control ( 29251981) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Parkinson's disease ( 26227905) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma thyroid-stimulating hormone levels ( 28333968) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Systolic blood pressure ( 27841878) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335)
Interacting Genes		2 interacting genes: NOP58 PDE10A	3 interacting genes: CASP3 TOP1 WDR3
Entrez ID		10885	10846
HPRD ID		16066	17828
Ensembl ID		ENSG00000065183	ENSG00000112541
Uniprot IDs		Q5TDG3 Q9UNX4	A0A1B1UZQ1 A0A1B1UZR0 Q9Y233
PDB IDs			1LRB 2OUN 2OUP 2OUQ 2OUR 2OUS 2OUU 2OUV 2OUY 2WEY 2Y0J 2ZMF 3SN7 3SNI 3SNL 3UI7 3UUO 3WI2 3WS8 3WS9 3WYK 3WYL 3WYM 4AEL 4AJD 4AJF 4AJG 4AJM 4BBX 4DDL 4DFF 4FCB 4FCD 4HEU 4HF4 4LKQ 4LLJ 4LLK 4LLP 4LLX 4LM0 4LM1 4LM2 4LM3 4LM4 4MRW 4MRZ 4MS0 4MSA 4MSC 4MSE 4MSH 4MSN 4MUW 4MVH 4P0N 4P1R 4PHW 4TPM 4TPP 4WN1 4XY2 4YQH 4YS7 4ZO5 5AXP 5AXQ 5B4K 5B4L 5C1W 5C28 5C29 5C2A 5C2E 5C2H 5DH4 5DH5 5EDE 5EDG 5EDH 5EDI 5I2R 5K9R 5UWF 5XUI 5XUJ 5ZNL 6IJH 6IJI 6KDX 6KDZ 6KE0 6KO0 6KO1 6KZE 6MSA 6MSC
Enriched GO Terms of Interacting Partners?
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