PGRMC1 and EVI2B

Data Source:
BioGRID (two hybrid)

		PGRMC1	EVI2B
Description		progesterone receptor membrane component 1	ecotropic viral integration site 2B
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Endomembrane System Membrane Smooth Endoplasmic Reticulum Membrane Specific Granule Membrane Neuron Projection Neuronal Cell Body Cell Body Synapse	Integral Component Of Plasma Membrane
	Molecular Function	Amyloid-beta Binding Steroid Binding Protein Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Heme Biosynthetic Process Neutrophil Degranulation	Positive Regulation Of Granulocyte Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Neutrophil Differentiation Myeloid Cell Development Negative Regulation Of Cell Cycle Arrest Regulation Of Stem Cell Division
Pathways		Neutrophil degranulation
Drugs		Dextromethorphan Nortriptyline Sertraline
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Oily fish consumption ( 32066663) Pork consumption ( 32066663)
Interacting Genes		20 interacting genes: BIK CAMLG CCDC134 CENPU CIAO1 CREB3L1 DEFB124 EVI2B GET3 GLP1R GOLM1 KASH5 KCNE5 MTNR1A PAM16 PGRMC2 SCAP SGTB TMEM213 ZNF71	31 interacting genes: APOD AQP1 AQP3 BTN2A2 CDIPT CLN6 CNIH1 DESI1 DRAM1 FAM3C FUNDC2 GALNT15 GIMAP5 MYADML2 NINJ2 NSG1 PGRMC1 RTP2 SCAMP4 SLC2A5 SLC30A2 SLC38A7 SLC39A9 TMEM107 TMEM222 TMEM60 TMEM86B TRAF3IP3 TRAM1L1 UBIAD1 VAMP4
Entrez ID		10857	2124
HPRD ID		02338	08867
Ensembl ID		ENSG00000101856	ENSG00000185862
Uniprot IDs		O00264 Q6IB11	P34910 Q9BRW1
PDB IDs		4X8Y
Enriched GO Terms of Interacting Partners?
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