NCKAP1 and MYO16

Data Source:
BioGRID (pull down)

		NCKAP1	MYO16
Description		NCK associated protein 1	myosin XVI
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Cytosol Focal Adhesion Integral Component Of Membrane Lamellipodium SCAR Complex Lamellipodium Membrane Filamentous Actin Extracellular Exosome	Nucleoplasm Cytoplasm Plasma Membrane Myosin Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Small GTPase Binding	Motor Activity Protein Binding ATP Binding Protein Phosphatase Binding Actin Filament Binding
	Biological Process	Cell Morphogenesis Apoptotic Process Central Nervous System Development Positive Regulation Of Lamellipodium Assembly Viral Process Cell Migration Rac Protein Signal Transduction Cell Projection Assembly Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Negative Regulation Of Cell Population Proliferation Phosphatidylinositol 3-kinase Signaling Cerebellum Development Neuron Projection Morphogenesis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Neurological blood protein biomarker levels ( 31320639)	Alzheimer's disease ( 30636644) Alzheimer's disease (cognitive decline) ( 23535033) Blood pressure ( 22763476) Chronotype ( 30696823) Colorectal cancer ( 29228715) Dental caries ( 23064961) Eosinophil counts ( 32888494) Lung function (FEV1/FVC) ( 30804560) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494) Nose size ( 27182965) Obesity-related traits ( 23251661) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Presence of antiphospholipid antibodies ( 23509613) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494) Resting-state electroencephalogram vigilance ( 29703947) Seasonality ( 25562672) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		14 interacting genes: ABI1 BRK1 CYFIP2 DNMBP GAS7 MYO16 NCK1 NYAP1 NYAP2 RAC1 SPP1 WASF1 WASF2 YWHAG	6 interacting genes: CYFIP1 NCKAP1 NRXN1 PIK3R1 PPP1CA PPP1CC
Entrez ID		10787	23026
HPRD ID		05353	14795
Ensembl ID		ENSG00000061676	ENSG00000041515
Uniprot IDs		Q9Y2A7	F8W883 Q9Y6X6
PDB IDs		3P8C 4N78
Enriched GO Terms of Interacting Partners?
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