NCKAP1 and WASF2

Data Source:
BioGRID (biochemical)
HPRD (in vivo)

		NCKAP1	WASF2
Description		NCK associated protein 1	WASP family member 2
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GO Annotations	Cellular Component	Ruffle Cytosol Focal Adhesion Integral Component Of Membrane Lamellipodium SCAR Complex Lamellipodium Membrane Filamentous Actin Extracellular Exosome	Ruffle Early Endosome Cytosol Cell-cell Junction Actin Cytoskeleton Basolateral Plasma Membrane Lamellipodium SCAR Complex Protein-containing Complex Synapse Extracellular Exosome
	Molecular Function	Protein Binding Small GTPase Binding	Actin Binding Protein Binding SH3 Domain Binding Protein Kinase A Regulatory Subunit Binding Cadherin Binding Protein Kinase A Binding Arp2/3 Complex Binding
	Biological Process	Cell Morphogenesis Apoptotic Process Central Nervous System Development Positive Regulation Of Lamellipodium Assembly Viral Process Cell Migration Rac Protein Signal Transduction Cell Projection Assembly Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation	Angiogenesis Ameboidal-type Cell Migration Endocytosis Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Lamellipodium Assembly Viral Process Rac Protein Signal Transduction Lamellipodium Assembly Actin Cytoskeleton Organization Actin Filament-based Movement Megakaryocyte Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Stress Fiber Assembly Lamellipodium Morphogenesis Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Neurological blood protein biomarker levels ( 31320639)	Systolic blood pressure ( 30578418)
Interacting Genes		14 interacting genes: ABI1 BRK1 CYFIP2 DNMBP GAS7 MYO16 NCK1 NYAP1 NYAP2 RAC1 SPP1 WASF1 WASF2 YWHAG	23 interacting genes: ABI1 ABI2 ABI3 ABL1 ACTB ACTR2 ACTR3 APBB1 ARPC3 BAIAP2 BTK CDC42 CYFIP2 DOCK1 FYN GAS7 GRB2 ITSN2 NCKAP1 PACSIN1 PRPF40A PSTPIP1 TCERG1
Entrez ID		10787	10163
HPRD ID		05353	05796
Ensembl ID		ENSG00000061676	ENSG00000158195
Uniprot IDs		Q9Y2A7	Q9Y6W5
PDB IDs		3P8C 4N78	2A40
Enriched GO Terms of Interacting Partners?
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