WDR4 and FEN1

Data Source:
BioGRID (pull down, pull down)

		WDR4	FEN1
Description		WD repeat domain 4	flap structure-specific endonuclease 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol TRNA Methyltransferase Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Mitochondrion Membrane Protein-containing Complex
	Molecular Function	Protein Binding TRNA (guanine-N7-)-methyltransferase Activity	Magnesium Ion Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding Double-stranded DNA Exodeoxyribonuclease Activity 5'-3' Exonuclease Activity 5'-flap Endonuclease Activity Manganese Ion Binding Flap Endonuclease Activity
	Biological Process	TRNA Modification Cellular Response To DNA Damage Stimulus TRNA (guanine-N7)-methylation	Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Base-excision Repair Double-strand Break Repair Memory UV Protection Telomere Maintenance Via Semi-conservative Replication DNA Replication, Removal Of RNA Primer Positive Regulation Of Sister Chromatid Cohesion Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		tRNA modification in the nucleus and cytosol	POLB-Dependent Long Patch Base Excision Repair Early Phase of HIV Life Cycle Removal of the Flap Intermediate from the C-strand PCNA-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) Removal of the Flap Intermediate
Drugs			Iron Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS		Blood and toenail selenium levels ( 25343990) Fasting plasma glucose ( 28270201)	Asthma ( 31959851 31619474) Bipolar disorder ( 28115744 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Colorectal cancer ( 24836286) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 28067908) Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hemoglobin levels ( 32327693) Laryngeal squamous cell carcinoma ( 25194280) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483 23378610) Oleic acid (18:1n-9) levels ( 23362303) Palmitoleic acid (16:1n-7) levels ( 23362303) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Platelet count ( 22139419) QT interval ( 29874175) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278) Resting heart rate ( 27798624) Serum metabolite levels ( 23093944) Serum metabolite ratios in chronic kidney disease ( 29545352) Stearic acid (18:0) levels ( 23362303)
Interacting Genes		6 interacting genes: FAM118A FEN1 METTL1 RABGGTB TERF1 TERF2	18 interacting genes: APEX1 APP ARHGDIA BLM CCNA2 CDK1 CDK2 EEF1G EP300 GSK3B HNRNPA1 HUS1 PCNA RAD1 RAD9A TERF1 WDR4 WRN
Entrez ID		10785	2237
HPRD ID		09330	02670
Ensembl ID		ENSG00000160193	ENSG00000168496
Uniprot IDs		P57081	P39748 Q6FHX6
PDB IDs			1U7B 1UL1 3Q8K 3Q8L 3Q8M 3UVU 5E0V 5FV7 5K97 5KSE 5UM9 5ZOD 5ZOE 5ZOF 5ZOG 6TNZ
Enriched GO Terms of Interacting Partners?
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