TOB2 and BHLHE40

Data Source:
BioGRID (two hybrid)

		TOB2	BHLHE40
Description		transducer of ERBB2, 2	basic helix-loop-helix family member e40
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Chromatin Nucleus Cytoplasm Nuclear Body
	Molecular Function	Transcription Corepressor Activity Protein Binding Vitamin D Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Female Gamete Generation Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Ossification Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Anterior/posterior Pattern Specification Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Regulation Of Neurogenesis
Pathways			BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310) Autism spectrum disorder or schizophrenia ( 28540026) Meat-related diet ( 32066663) Neuroticism ( 29255261) Refractive error ( 32231278) Vitiligo ( 22561518)	Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Psoriasis vulgaris ( 26626624) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		5 interacting genes: BHLHE40 CEP76 CNOT7 CNOT8 RPS6KA1	89 interacting genes: AAMP AANAT APH1A ARNTL ATXN1 BHLHE41 BRD7 BYSL CALML3 CCNK CDPF1 CHD3 COX5B CREM DAB1 DAZAP2 DVL3 EHHADH ENO1 FAM83A FBLN1 GMCL2 GPSM1 HDAC1 HIVEP1 HNRNPLL KLHDC7B KRTAP1-3 KRTAP19-1 KRTAP19-5 KRTAP19-7 KRTAP23-1 KRTAP6-1 KRTAP6-2 KRTAP8-1 LARP4 LASP1 LMO3 MAGED1 MCRS1 MYOD1 NAA50 NEK6 NOC4L NUMBL PDE6G PFDN5 PHF1 PLEKHB2 POU6F2 PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E RAD54L2 RBFOX1 RBM23 RBPMS RBPMS2 RHOBTB3 RHOJ ROR2 SETDB1 SIN3A SMAP2 SMARCB1 SMYD1 SOGA1 SOX15 STAT3 STK19 TCF3 TENT5A TENT5B TLE5 TOB2 TOLLIP TTC23 TXNL4B UBE2I USP54 VAC14 VENTX VIM WT1 ZFHX3 ZHX1
Entrez ID		10766	8553
HPRD ID		09583	16050
Ensembl ID		ENSG00000183864	ENSG00000134107
Uniprot IDs		Q14106	O14503 Q6IB83
PDB IDs
Enriched GO Terms of Interacting Partners?
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