USP16 and SGIP1

Data Source:
HPRD (in vivo)

		USP16	SGIP1
Description		ubiquitin specific peptidase 16	SH3GL interacting endocytic adaptor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit AP-2 Adaptor Complex Clathrin-coated Vesicle
	Molecular Function	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Zinc Ion Binding Histone Binding Ubiquitin Binding	Protein Binding Phospholipid Binding Microtubule Binding SH3 Domain Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Monoubiquitinated Histone H2A Deubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Translational Elongation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Cell Division Regulation Of Cell Cycle Histone H2A K63-linked Deubiquitination Mitotic Nuclear Division	Response To Dietary Excess Positive Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Membrane Organization Clathrin-dependent Endocytosis Energy Homeostasis Positive Regulation Of Feeding Behavior
Pathways		Ub-specific processing proteases	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS			Automobile speeding propensity ( 30643258) Cerebellum white matter volume ( 31530798) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Chronotype ( 30696823) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Menopause (age at onset) ( 23307926) Presence of antiphospholipid antibodies ( 23509613) Pulse pressure ( 30224653 30578418) Systolic blood pressure ( 30578418) TPE interval (resting) ( 32386560) Ulcerative colitis ( 28067908)
Interacting Genes		15 interacting genes: CALM1 CDK1 EXOSC10 FBXO11 H2AC18 H2AC20 H2AC4 H2AZ1 H2BC3 H4-16 PLK1 PTOV1 TTK UBC UBD	5 interacting genes: APP DAB2 EPS15 EPS15L1 ITSN1
Entrez ID		10600	84251
HPRD ID		06881	10910
Ensembl ID		ENSG00000156256	ENSG00000118473
Uniprot IDs		Q9Y5T5	Q9BQI5
PDB IDs		2I50	5AWR 5AWS 5AWT 5AWU 6A9Y
Enriched GO Terms of Interacting Partners?
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