CCT4 and CCNE1

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		CCT4	CCNE1
Description		chaperonin containing TCP1 subunit 4	cyclin E1
Image
GO Annotations	Cellular Component	Zona Pellucida Receptor Complex Nucleoplasm Centrosome Cytosol Chaperonin-containing T-complex Microtubule Melanosome Cell Projection Cell Body Extracellular Exosome	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cyclin E1-CDK2 Complex
	Molecular Function	RNA Binding Protein Binding ATP Binding Protein Folding Chaperone Unfolded Protein Binding	Protein Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Positive Regulation Of Telomerase Activity ScaRNA Localization To Cajal Body Toxin Transport Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Telomere Maintenance DNA Replication Initiation Protein Phosphorylation Homologous Chromosome Pairing At Meiosis Wnt Signaling Pathway Mitotic Cell Cycle Phase Transition Cell Division Positive Regulation Of Mesenchymal Stem Cell Proliferation Regulation Of Cellular Protein Localization
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response PTK6 Regulates Cell Cycle Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) RHOBTB3 ATPase cycle
Drugs
Diseases			Laryngeal cancer Gastric cancer
GWAS		Erectile dysfunction ( 30583798) Plasma free amino acid levels ( 30659259)	Adult body size ( 32376654) Bladder cancer ( 24163127 20972438) Body mass index ( 25673413) Breast cancer ( 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) Diastolic blood pressure ( 28135244 27841878) Medication use (diuretics) ( 31015401) Response to fenofibrate (total cholesterol levels) ( 27002377) Spatial processing ( 31596458)
Interacting Genes		15 interacting genes: ACTA1 ACTA2 ACTB CCNE1 CCNH CCT2 CFAP52 COP1 LINC01554 MTDH PRPF40A PTEN RPS6KA1 SUMO2 VRK2	70 interacting genes: AKT1 AR ARHGEF5 ARID4A ARIH1 ARNT AURKA BRCA2 BTRC CABLES1 CALM1 CCND2 CCT4 CDC25A CDC6 CDK1 CDK2 CDK3 CDK4 CDK6 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C COIL CUL3 FBXW7 FGFR4 FOXM1 FZR1 GLIS2 GMNC GRM1 GSK3B H1-0 H1-1 H1-5 HERC5 KAT2A LATS2 MARCKS MCM3 MRE11 MYBL2 MYC NBN NF2 PIN1 POLD1 PRC1 PRKAR1A PTPA RASSF1 RB1 RBL1 RBL2 REL RHOBTB3 RRN3 SKP2 SMARCA4 SMARCC1 SMARCD3 SPOP STK11 TERT TP73 TSC1 UBTF
Entrez ID		10575	898
HPRD ID		05506	00455
Ensembl ID		ENSG00000115484	ENSG00000105173
Uniprot IDs		P50991	A0A0G3DHS8 P24864 V5W5X2
PDB IDs		6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8	1W98 5L2W
Enriched GO Terms of Interacting Partners?
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