SLU7 and ARHGEF5

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)

		SLU7	ARHGEF5
Description		SLU7 homolog, splicing factor	Rho guanine nucleotide exchange factor 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Membrane Nuclear Speck Small Nuclear Ribonucleoprotein Complex Intracellular Membrane-bounded Organelle Catalytic Step 2 Spliceosome	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Junction Cell Projection Cell Periphery
	Molecular Function	Second Spliceosomal Transesterification Activity Protein Binding Zinc Ion Binding Pre-mRNA 3'-splice Site Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Lipid Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions Alternative MRNA Splicing, Via Spliceosome MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome RNA Export From Nucleus MRNA Export From Nucleus Intracellular Protein Transport RNA Splicing MRNA 3'-end Processing Cellular Response To Heat	G Protein-coupled Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Regulation Of ERK1 And ERK2 Cascade Activation Of GTPase Activity Positive Regulation Of Protein Import
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Asthma ( 32296059) Common carotid intima-media thickness ( 29206233)	Breast cancer ( 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Gut microbiota relative abundance (Parabacteroides) ( 33208821) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		27 interacting genes: AIMP2 BAG2 CCDC85B CEP70 DEF6 FHL3 GOLGA2 GTF2I IKBKG JMJD6 KDM1A KRT40 LMNA LONRF1 LZTS2 MCC NFKBID NSD3 PCBP2 PIBF1 PPIG PPIL3 PRMT5 PRMT6 TEPSIN THAP1 ZCCHC10	28 interacting genes: APP ATP13A1 CALCOCO2 CCNE1 CHPF COG6 EFHC2 EPM2AIP1 FKBP8 HSF2BP HSPBAP1 LMO2 LRATD1 MB21D2 MID2 NR4A1 PICK1 PLCG1 PLEKHG4 POLR1C RHOA SEPHS2 SLAIN1 TBC1D13 TCF4 TRIM27 TRIM54 ZRANB1
Entrez ID		10569	7984
HPRD ID		12074	02932
Ensembl ID		ENSG00000164609	ENSG00000050327
Uniprot IDs		O95391	Q12774
PDB IDs		5XJC 6ICZ 6QDV
Enriched GO Terms of Interacting Partners?
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