ARHGEF5 and MB21D2

Data Source:
BioGRID (two hybrid)

		ARHGEF5	MB21D2
Description		Rho guanine nucleotide exchange factor 5	Mab-21 domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Junction Cell Projection Cell Periphery
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP Binding Lipid Binding	Protein Binding Protein-containing Complex Binding Cadherin Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly Regulation Of ERK1 And ERK2 Cascade Activation Of GTPase Activity Positive Regulation Of Protein Import
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Gut microbiota relative abundance (Parabacteroides) ( 33208821) Post bronchodilator FEV1/FVC ratio ( 26634245)	Anti-saccade response ( 29064472)
Interacting Genes		28 interacting genes: APP ATP13A1 CALCOCO2 CCNE1 CHPF COG6 EFHC2 EPM2AIP1 FKBP8 HSF2BP HSPBAP1 LMO2 LRATD1 MB21D2 MID2 NR4A1 PICK1 PLCG1 PLEKHG4 POLR1C RHOA SEPHS2 SLAIN1 TBC1D13 TCF4 TRIM27 TRIM54 ZRANB1	13 interacting genes: ARHGEF5 ATXN7L2 BYSL CBX8 CIR1 DTNB EVI5 MORN3 RAB3IP REL SLC12A4 SPRY1 SPRY2
Entrez ID		7984	151963
HPRD ID		02932	14092
Ensembl ID		ENSG00000050327	ENSG00000180611
Uniprot IDs		Q12774	Q8IYB1
PDB IDs
Enriched GO Terms of Interacting Partners?
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