TESK2 and DSTN

Data Source:
HPRD (in vitro)

		TESK2	DSTN
Description		testis associated actin remodelling kinase 2	destrin, actin depolymerizing factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body	Cytoplasm Actin Cytoskeleton Cortical Actin Cytoskeleton Extracellular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Binding Actin Filament Binding
	Biological Process	Protein Phosphorylation Spermatogenesis Peptidyl-tyrosine Phosphorylation Actin Cytoskeleton Organization Focal Adhesion Assembly	Actin Polymerization Or Depolymerization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Actin Filament Depolymerization Cell Motility Actin Filament Severing
Pathways
Drugs			Dodecyldimethylamine N-oxide
Diseases
GWAS		Blood protein levels ( 28240269) Chronic obstructive pulmonary disease ( 30804561) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252)	Coronary artery disease ( 29212778) Presence of antiphospholipid antibodies ( 23509613)
Interacting Genes		3 interacting genes: CFL1 DSTN YWHAB	8 interacting genes: ACTB ACTG1 CFL2 SHBG SMAD9 SSH1 TAX1BP1 TESK2
Entrez ID		10420	11034
HPRD ID		05298	16446
Ensembl ID		ENSG00000070759	ENSG00000125868
Uniprot IDs		B4DFN2 Q96S53	P60981 V9HWA6
PDB IDs
Enriched GO Terms of Interacting Partners?
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