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NDRG1 and RPS3
Data Source:
HPRD
(in vivo)
NDRG1
RPS3
Description
N-myc downstream regulated 1
ribosomal protein S3
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Centrosome
Cytosol
Microtubule
Plasma Membrane
Adherens Junction
Microtubule Cytoskeleton
Perinuclear Region Of Cytoplasm
Recycling Endosome Membrane
Extracellular Exosome
Glutamatergic Synapse
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrial Inner Membrane
Mitochondrial Matrix
Endoplasmic Reticulum
Cytosol
Ribosome
Polysome
Plasma Membrane
Focal Adhesion
Postsynaptic Density
Membrane
Cytosolic Small Ribosomal Subunit
Ruffle Membrane
Extracellular Exosome
NF-kappaB Complex
Mitotic Spindle
Ribonucleoprotein Complex
Molecular Function
Protein Binding
Microtubule Binding
Small GTPase Binding
Gamma-tubulin Binding
Cadherin Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
Damaged DNA Binding
RNA Binding
MRNA Binding
Structural Constituent Of Ribosome
DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
Endodeoxyribonuclease Activity
Protein Binding
Microtubule Binding
Transcription Factor Binding
Tubulin Binding
DNA N-glycosylase Activity
Enzyme Binding
Kinase Binding
Protein Kinase Binding
Hsp70 Protein Binding
Oxidized Purine DNA Binding
Oxidized Pyrimidine DNA Binding
Ubiquitin-like Protein Conjugating Enzyme Binding
Protein-containing Complex Binding
Protein Kinase A Binding
Iron-sulfur Cluster Binding
Hsp90 Protein Binding
Small Ribosomal Subunit RRNA Binding
Supercoiled DNA Binding
Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
Biological Process
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Response To Metal Ion
DNA Damage Response, Signal Transduction By P53 Class Mediator
Peripheral Nervous System Myelin Maintenance
Regulation Of Apoptotic Process
Mast Cell Activation
Cellular Response To Hypoxia
Postsynapse Organization
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
DNA Repair
Translation
Translational Initiation
SRP-dependent Cotranslational Protein Targeting To Membrane
Apoptotic Process
Cellular Response To DNA Damage Stimulus
Chromosome Segregation
Positive Regulation Of Gene Expression
Negative Regulation Of Translation
Viral Transcription
Positive Regulation Of Microtubule Polymerization
Positive Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Endodeoxyribonuclease Activity
Positive Regulation Of Interleukin-2 Production
Cellular Response To Reactive Oxygen Species
Positive Regulation Of Activated T Cell Proliferation
DNA Damage Response, Detection Of DNA Damage
Regulation Of Apoptotic Process
Positive Regulation Of JUN Kinase Activity
Negative Regulation Of DNA Repair
Positive Regulation Of DNA Repair
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Spindle Assembly
Cell Division
Response To TNF Agonist
Cellular Response To Hydrogen Peroxide
Cellular Response To Tumor Necrosis Factor
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of DNA N-glycosylase Activity
Positive Regulation Of Base-excision Repair
Positive Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Response of EIF2AK4 (GCN2) to amino acid deficiency
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Estimated glomerular filtration rate (
31015462
)
Left-handedness (
32989287
)
Nontyphoidal Salmonella bacteraemia (
29523850
)
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
Interacting Genes
70 interacting genes:
ACSL3
ACTG1
AP1M2
AP2M1
APOA1
APOA2
ARL4D
ATP1A1
CANX
CDH1
CLTC
CNDP2
COPB2
CTNNB1
DDX1
DDX5
DLST
EEF1G
EEF2
EIF2S3
EIF3E
EWSR1
FASN
GSK3B
HNRNPF
HNRNPH1
HNRNPU
HSD17B4
HSP90AA1
HSPA5
ILF3
KIF5B
LDHA
MAOA
MLH1
MME
MYC
NCL
NR4A1
PABPC1
PHYHIP
PKM
PPP2R2A
PRKACA
PSMC2
PSMC3
PSMD2
RPL24
RPL3
RPL4
RPN2
RPS16
RPS20
RPS26
RPS3
RPS6
RPS8
RTN1
RUVBL2
S100B
SEC23A
SGK1
SHMT2
TAF9
TARS1
TLE3
UPF1
VCP
XRCC5
ZNF155
20 interacting genes:
ATP6V0D2
CCT2
CSNK2A1
DDIT3
DUX4
FOLH1
HSP90AA1
IL7R
LTV1
MDM2
NDRG1
NFKB1
PTEN
RELA
RPL9
SUMO1
SUMO2
UBC
WBP2
YWHAQ
Entrez ID
10397
6188
HPRD ID
05586
10941
Ensembl ID
ENSG00000104419
ENSG00000149273
Uniprot IDs
B3KWB2
Q8N959
Q92597
P23396
PDB IDs
1WH9
4UG0
4V6X
5A2Q
5AJ0
5FLX
5LKS
5OA3
5T2C
5VYC
6EK0
6FEC
6G51
6G53
6G5H
6G5I
6IP5
6IP6
6IP8
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6XA1
6Y0G
6Y2L
6Y57
6YBS
6Z6L
6Z6M
6Z6N
6ZLW
6ZM7
6ZME
6ZMI
6ZMO
6ZMT
6ZMW
6ZN5
6ZOJ
6ZOL
6ZON
6ZP4
6ZVH
6ZVJ
7A09
7K5I
Enriched GO Terms of Interacting Partners
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