ABCA8 and BACE2

Data Source:
BioGRID (affinity chromatography technology)

		ABCA8	BACE2
Description		ATP binding cassette subfamily A member 8	beta-secretase 2
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Intracellular Membrane-bounded Organelle	Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Integral Component Of Membrane Dense Core Granule
	Molecular Function	Lipid Transporter Activity ATP Binding ABC-type Xenobiotic Transporter Activity ATPase-coupled Transmembrane Transporter Activity ABC-type Transporter Activity	Aspartic-type Endopeptidase Activity Protein Binding
	Biological Process	Sphingomyelin Biosynthetic Process Lipid Transport Regulation Of Cholesterol Efflux Positive Regulation Of Cholesterol Efflux Cholesterol Transport Cholesterol Efflux Xenobiotic Transport Transmembrane Transport	Proteolysis Membrane Protein Ectodomain Proteolysis Peptide Hormone Processing Glucose Homeostasis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Astrocyte Activation Amyloid-beta Metabolic Process
Pathways		ABC-family proteins mediated transport
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Cholesterol, total ( 26582766) Coronary artery disease ( 29212778) group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 32203549 28334899) Late-onset Alzheimer's disease ( 27770636) LDL cholesterol ( 25961943) Phosphorus levels ( 29403010) Soluble VCAM-1 levels ( 31217265) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577)	Adult body size ( 32376654) Body mass index ( 25673413) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Elevated fasting plasma glucose ( 30004843) Glycemic traits (pregnancy) ( 23903356)
Interacting Genes			3 interacting genes: APP GGA1 GGA2
Entrez ID		10351	25825
HPRD ID		09790	05744
Ensembl ID		ENSG00000141338	ENSG00000182240
Uniprot IDs		A0A024R8L6 A0A0A0MSU4 O94911	Q9Y5Z0
PDB IDs			2EWY 3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ 3ZKS 3ZKX 3ZL7 3ZLQ 4BEL 4BFB 6JSZ 6UJ0 6UJ1
Enriched GO Terms of Interacting Partners?
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