ADAR and HDLBP

Data Source:
HPRD (in vitro)

		ADAR	HDLBP
Description		adenosine deaminase RNA specific	high density lipoprotein binding protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Supraspliceosomal Complex	Nucleus Cytoplasm Cytosol Polysome Plasma Membrane High-density Lipoprotein Particle
	Molecular Function	DNA Binding RNA Binding Double-stranded RNA Binding Double-stranded RNA Adenosine Deaminase Activity Protein Binding TRNA-specific Adenosine Deaminase Activity Metal Ion Binding	RNA Binding MRNA Binding Protein Binding Lipid Binding Cadherin Binding
	Biological Process	Osteoblast Differentiation Hematopoietic Progenitor Cell Differentiation Somatic Diversification Of Immune Receptors Via Somatic Mutation Adenosine To Inosine Editing RNA Processing MRNA Processing Response To Virus Base Conversion Or Substitution Editing Erythrocyte Differentiation Pre-miRNA Processing MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA Response To Interferon-alpha Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Definitive Hemopoiesis Type I Interferon Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway Hematopoietic Stem Cell Homeostasis Cellular Response To Virus Negative Regulation Of RNA Interference	Lipid Transport Cholesterol Metabolic Process High-density Lipoprotein Particle Clearance
Pathways		C6 deamination of adenosine Formation of editosomes by ADAR proteins Interferon alpha/beta signaling	HDL clearance
Drugs
Diseases		Dyschromatosis symmetrica hereditaria
GWAS		Apolipoprotein A1 levels ( 32203549) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Lung cancer ( 28604730) Prostate cancer ( 23535732) Squamous cell lung carcinoma ( 28604730)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Fibrinogen levels ( 28107422 26561523) HDL cholesterol levels ( 32203549) Intraocular pressure ( 29617998) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625)
Interacting Genes		6 interacting genes: ERG HDLBP PTEN TGM2 UBE2I XPO1	13 interacting genes: ADAR CDC42 CSNK2A1 DHX9 ERBB2 ESR1 HMGB2 HSPB1 SMAD4 SOS1 SUMO2 TENT5A XPOT
Entrez ID		103	3069
HPRD ID		07528	00813
Ensembl ID		ENSG00000160710	ENSG00000115677
Uniprot IDs		P55265	A0A024R4E5 B2R5V9 Q00341
PDB IDs		1QBJ 1QGP 1XMK 2ACJ 2GXB 2L54 2MDR 3F21 3F22 3F23 3IRQ 3IRR 5ZU1 5ZUO 5ZUP	1VIG 1VIH 2CTE 2CTF 2CTJ 2CTK 2CTL 2CTM
Enriched GO Terms of Interacting Partners?
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