HDLBP and HMGB2

Data Source:
BioGRID (two hybrid)

		HDLBP	HMGB2
Description		high density lipoprotein binding protein	high mobility group box 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Polysome Plasma Membrane High-density Lipoprotein Particle	Chromatin Condensed Chromosome Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding MRNA Binding Protein Binding Lipid Binding Cadherin Binding	Four-way Junction DNA Binding Transcription Regulatory Region Sequence-specific DNA Binding Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Protein Domain Specific Binding Chemoattractant Activity Non-sequence-specific DNA Binding, Bending RAGE Receptor Binding Supercoiled DNA Binding
	Biological Process	Lipid Transport Cholesterol Metabolic Process High-density Lipoprotein Particle Clearance	Positive Regulation Of Endothelial Cell Proliferation Inflammatory Response To Antigenic Stimulus DNA Topological Change Double-strand Break Repair Via Nonhomologous End Joining Apoptotic DNA Fragmentation Chromatin Organization Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Spermatid Nucleus Differentiation Male Gonad Development Positive Regulation Of Nuclease Activity DNA Geometric Change Response To Lipopolysaccharide Positive Regulation Of Interferon-beta Production V(D)J Recombination Positive Regulation Of DNA Binding Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Regulation Of Neurogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis Cell Chemotaxis Cellular Response To Lipopolysaccharide Regulation Of Stem Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		HDL clearance	Apoptosis induced DNA fragmentation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Fibrinogen levels ( 28107422 26561523) HDL cholesterol levels ( 32203549) Intraocular pressure ( 29617998) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 23535732) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625)
Interacting Genes		13 interacting genes: ADAR CDC42 CSNK2A1 DHX9 ERBB2 ESR1 HMGB2 HSPB1 SMAD4 SOS1 SUMO2 TENT5A XPOT	38 interacting genes: APEX1 APP AR ARCN1 C1QBP CACTIN CHAF1A CREBBP CSNK1A1 EIF1 FBXO7 GZMA GZMK H3-3A HACD3 HDLBP HMGA1 LZTS1 MIEN1 NAP1L1 NCBP3 NEXN NR3C1 PGR PKNOX1 POU2F1 POU2F2 POU3F1 POU5F1 PRKDC RAG1 SAMM50 SET TP53 TSNAX ZNF428 ZNF622 ZNF668
Entrez ID		3069	3148
HPRD ID		00813	01229
Ensembl ID		ENSG00000115677	ENSG00000164104
Uniprot IDs		A0A024R4E5 B2R5V9 Q00341	P26583
PDB IDs		1VIG 1VIH 2CTE 2CTF 2CTJ 2CTK 2CTL 2CTM
Enriched GO Terms of Interacting Partners?
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