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MAP2K7 and RANBP2
Data Source:
BioGRID
(enzymatic study, affinity chromatography technology)
MAP2K7
RANBP2
Description
mitogen-activated protein kinase kinase 7
RAN binding protein 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Nuclear Envelope
Annulate Lamellae
Nuclear Pore
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Membrane
Nuclear Membrane
Nuclear Inclusion Body
Intracellular Membrane-bounded Organelle
Host Cell
Nuclear Pore Cytoplasmic Filaments
Nuclear Pore Nuclear Basket
Cytoplasmic Periphery Of The Nuclear Pore Complex
Molecular Function
Magnesium Ion Binding
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Activity
Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
JUN Kinase Kinase Activity
Enzyme Binding
Protein Kinase Binding
Protein Phosphatase Binding
RNA Binding
Peptidyl-prolyl Cis-trans Isomerase Activity
GTPase Activator Activity
Protein Binding
Cyclosporin A Binding
SUMO Transferase Activity
Small GTPase Binding
Protein-containing Complex Binding
Metal Ion Binding
Biological Process
Activation Of MAPK Activity
Apoptotic Process
Response To Osmotic Stress
Signal Transduction
JNK Cascade
Activation Of JUN Kinase Activity
Response To Heat
Response To UV
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Telomere Maintenance Via Telomerase
Response To Tumor Necrosis Factor
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Stress-activated MAPK Cascade
Positive Regulation Of Telomerase Activity
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Telomere Capping
Protein Peptidyl-prolyl Isomerization
Response To Amphetamine
Regulation Of Glycolytic Process
Regulation Of Gluconeogenesis
MRNA Export From Nucleus
TRNA Export From Nucleus
Protein Folding
NLS-bearing Protein Import Into Nucleus
Viral Process
Protein Sumoylation
Viral Transcription
Positive Regulation Of Glucokinase Activity
Positive Regulation Of GTPase Activity
Centrosome Localization
Regulation Of Gene Silencing By MiRNA
Intracellular Transport Of Virus
Regulation Of Cellular Response To Heat
Pathways
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Uptake and function of anthrax toxins
ISG15 antiviral mechanism
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Transport of the SLBP independent Mature mRNA
Transport of the SLBP Dependant Mature mRNA
Transport of Mature mRNA Derived from an Intronless Transcript
Transport of Mature mRNA derived from an Intron-Containing Transcript
Rev-mediated nuclear export of HIV RNA
Transport of Ribonucleoproteins into the Host Nucleus
NS1 Mediated Effects on Host Pathways
Viral Messenger RNA Synthesis
NEP/NS2 Interacts with the Cellular Export Machinery
Regulation of Glucokinase by Glucokinase Regulatory Protein
Nuclear import of Rev protein
Vpr-mediated nuclear import of PICs
snRNP Assembly
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Nuclear Pore Complex (NPC) Disassembly
Regulation of HSF1-mediated heat shock response
SUMOylation of SUMOylation proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
Transcriptional regulation by small RNAs
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
RHO GTPases Activate Formins
tRNA processing in the nucleus
Mitotic Prometaphase
HCMV Early Events
HCMV Late Events
EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS
HDL cholesterol levels (
32203549
)
Mean corpuscular hemoglobin concentration (
32888494
)
Metabolite levels (
23823483
)
Type 2 diabetes (
30297969
32499647
)
Attention deficit hyperactivity disorder (
29325848
)
Beard thickness (
26926045
)
Monobrow thickness (
26926045
)
Scalp hair shape (
26926045
)
Interacting Genes
32 interacting genes:
ARR3
ATF4
CFLAR
CNKSR1
DUSP19
DUSP22
GADD45B
JUN
LPXN
LRRK2
MAP3K1
MAP3K11
MAP3K12
MAP3K13
MAP3K2
MAP3K20
MAP3K3
MAP3K4
MAP3K5
MAPK1
MAPK14
MAPK8
MAPK8IP1
MAPK8IP2
MAPK8IP3
MAPK9
MAPT
RANBP2
RPL30
TRAF6
TRIB1
VRK2
38 interacting genes:
AKAP13
ARID4B
CALM1
CDCA8
CUL1
FHOD1
HDAC4
IFT140
IPO5
KPNA1
KPNA2
KPNB1
LRPAP1
MAP2K7
MDM2
MYBPC2
NFX1
NUP62
NXF1
OPN1LW
OPN1MW
PDLIM3
PRKN
PTEN
RAN
RANGAP1
SENP1
SP100
SUMO1
SUMO2
TAF1
TNPO1
TOP2B
UBE2I
UBTD1
WAS
XPO1
XPOT
Entrez ID
5609
5903
HPRD ID
04309
03111
Ensembl ID
ENSG00000076984
ENSG00000153201
Uniprot IDs
B4DV95
O14733
P49792
PDB IDs
2DYL
3WZU
4UX9
5B2K
5B2L
5B2M
5Y8U
5Y90
5Z1D
5Z1E
6IB0
6IB2
6QFL
6QFR
6QFT
6QG4
6QG7
6QHO
6QHR
6YFZ
6YG0
6YG1
6YG2
6YG3
6YG4
6YG5
6YG6
6YG7
6YZ4
7CBX
1RRP
1XKE
1Z5S
2LAS
3UIN
3UIO
3UIP
4GA0
4I9Y
4L6E
4LQW
5CLL
5CLQ
Enriched GO Terms of Interacting Partners
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