ALYREF and UPF3A

Data Source:
HPRD (in vivo)

		ALYREF	UPF3A
Description		Aly/REF export factor	UPF3A regulator of nonsense mediated mRNA decay
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GO Annotations	Cellular Component	Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Speck Exon-exon Junction Complex Extracellular Exosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Exon-exon Junction Complex Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Binding Protein Binding C5-methylcytidine-containing RNA Binding	RNA Binding Protein Binding Structural Constituent Of Nuclear Pore Telomeric DNA Binding
	Biological Process	Regulation Of DNA Recombination MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Export From Nucleus MRNA Export From Nucleus Viral Process MRNA 3'-end Processing Replication Fork Processing Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleocytoplasmic Transport Positive Regulation Of Translation MRNA Transport
Pathways		Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Height ( 31562340) Nodular sclerosis Hodgkin lymphoma ( 29196614) Pulse pressure ( 30578418)
Interacting Genes		11 interacting genes: AKT1 DDX39B ESR1 IL7R LEF1 MAGOH NXF1 PTEN RUNX2 THOC6 UPF3A	9 interacting genes: ALYREF APP GSK3B IFITM2 NXF1 PIGT RBM8A SMG1 UPF1
Entrez ID		10189	65110
HPRD ID		09168	09274
Ensembl ID		ENSG00000183684	ENSG00000169062
Uniprot IDs		E9PB61 Q86V81	B3KUE7 Q9H1J1
PDB IDs		3ULH	2L08
Enriched GO Terms of Interacting Partners?
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