AKAP9 and MYO5A

Data Source:
BioGRID (two hybrid)

		AKAP9	MYO5A
Description		A-kinase anchoring protein 9	myosin VA
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Golgi Stack Cis-Golgi Network Centrosome Cytosol Cytoskeleton Voltage-gated Potassium Channel Complex Intracellular Membrane-bounded Organelle Synaptic Membrane Glutamatergic Synapse	Ruffle Cytoplasm Lysosome Early Endosome Late Endosome Peroxisome Endoplasmic Reticulum Cytosol Actin Filament Actin Cytoskeleton Membrane Myosin Complex Growth Cone Vesicle Filopodium Tip Insulin-responsive Compartment Melanosome Neuron Projection Recycling Endosome Extracellular Exosome
	Molecular Function	DNA Binding Signaling Receptor Binding Protein Binding Potassium Channel Regulator Activity Protein Kinase A Regulatory Subunit Binding Ion Channel Binding Molecular Adaptor Activity	Microfilament Motor Activity RNA Binding Protein Binding Calmodulin Binding ATP Binding Actin-dependent ATPase Activity Small GTPase Binding Actin Filament Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Nucleation Signal Transduction Chemical Synaptic Transmission Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Maintenance Of Centrosome Location Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Cellular Response To CAMP Regulation Of Heart Rate By Cardiac Conduction Ciliary Basal Body-plasma Membrane Docking Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Postsynaptic Neurotransmitter Receptor Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Golgi Organization	Post-Golgi Vesicle-mediated Transport Actin Filament Organization Protein Transport Vesicle-mediated Transport Actin Filament-based Movement Vesicle Transport Along Actin Filament Melanosome Transport Cellular Response To Insulin Stimulus Protein Localization To Plasma Membrane Regulation Of Golgi Organization
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Phase 3 - rapid repolarisation Phase 2 - plateau phase Anchoring of the basal body to the plasma membrane Signaling by BRAF and RAF fusions AURKA Activation by TPX2	Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of actin dynamics for phagocytic cup formation Insulin processing FCGR3A-mediated phagocytosis
Drugs
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)	Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Breast cancer ( 29059683) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Red blood cell count ( 32888494)	Mean platelet volume ( 32888494) Metabolite levels (Pyroglutamine) ( 23934736)
Interacting Genes		85 interacting genes: ABI2 BEX2 BLZF1 C1orf94 CALM1 CALM2 CALM3 CASK CCDC116 CCDC146 CCP110 CDC5L CEP55 CLIC1 CSNK1D CSNK1E CTBP1 CTNNA3 DVL2 FAM90A1 FMR1 FNBP1 FXR2 GLIS2 GPC4 GRIN1 GTSE1 HDDC3 HNRNPM IKZF3 KCNQ1 KDM1A KIF19 KLC4 LMO1 MAGEA6 MAGED1 MED1 MYO5A NDEL1 PARD6G PCM1 PCNT PKN1 PKP2 PPP1CA PPP2R1B PPP2R3A PRC1 PRDM14 PRKAR2A PRKAR2B PRKCE RBM10 RBM14 RPA2 RSRC2 SAMD3 SCNM1 SF3B2 SLAIN1 SNF8 SNRPB SSX2 SSX3 SSX5 SUV39H2 TACC3 TCEANC TDP2 TENT5B THAP1 THOC1 TLX3 TNIK TRIP10 TSG101 TSNAX TUBGCP3 TULP3 USHBP1 USO1 VPS9D1 WAC YWHAE	17 interacting genes: AKAP9 BMF CALM1 DLGAP1 DYNLL1 DYNLL2 KIF5B MLPH NDEL1 NEFL PRPH RAB11A RAB27A RAB3A RPH3A TRIM2 TRIM3
Entrez ID		10142	4644
HPRD ID		04921	01179
Ensembl ID		ENSG00000127914	ENSG00000197535
Uniprot IDs		Q5GIA7 Q6PJH3 Q99996	A8CDT9 Q9UES4 Q9Y4I1
PDB IDs			4D07 4J5L 4LLI 4LX1 4LX2 5JCY 5JCZ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?