FEM1B and PPM1F

Data Source:
BioGRID (affinity chromatography technology, pull down)

		FEM1B	PPM1F
Description		fem-1 homolog B	protein phosphatase, Mg2+/Mn2+ dependent 1F
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Cytosol Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Death Receptor Binding Protein Binding	Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Apoptotic Process Protein Ubiquitination Post-translational Protein Modification Regulation Of Ubiquitin-protein Transferase Activity Branching Involved In Prostate Gland Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of DNA Damage Checkpoint	Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Positive Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Cell-substrate Adhesion Histone Dephosphorylation Positive Regulation Of Cell Migration Negative Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Drug Peptidyl-threonine Dephosphorylation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Growth Positive Regulation Of Chemotaxis Negative Regulation Of Protein Transport Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Peptidyl-serine Dephosphorylation Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Localization Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Neddylation	Negative regulation of NMDA receptor-mediated neuronal transmission
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Major depressive disorder ( 23377640) Systolic blood pressure ( 26969751)	Adventurousness ( 30643258) Attention deficit hyperactivity disorder ( 18839057) Bipolar disorder ( 31043756)
Interacting Genes		7 interacting genes: APAF1 FAS GLI1 KIAA0319 NKX3-1 PPM1F RAD9A	19 interacting genes: AATK ARHGEF7 CAMK2A ERBB2 ERBB3 ERBB4 FAM161A FEM1A FEM1B KLHL8 LATS1 LMTK2 MARS1 MEOX1 PAK1 PRKAA1 PTK7 ROR1 ROR2
Entrez ID		10116	9647
HPRD ID		16889	10163
Ensembl ID		ENSG00000169018	ENSG00000100034
Uniprot IDs		Q9UK73	B5MCT7 P49593
PDB IDs		6LBF 7CNG
Enriched GO Terms of Interacting Partners?
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