ARPC2 and ARPC4

Data Source:
HPRD (two hybrid)

		ARPC2	ARPC4
Description		actin related protein 2/3 complex subunit 2	actin related protein 2/3 complex subunit 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Endosome Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Lamellipodium Site Of Double-strand Break Muscle Cell Projection Membrane Neuron Projection Extracellular Exosome Glutamatergic Synapse	Nucleus Cytosol Arp2/3 Protein Complex Site Of Double-strand Break Cell Projection Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	Structural Constituent Of Cytoskeleton Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Actin Filament Binding
	Biological Process	Positive Regulation Of Lamellipodium Assembly Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Ephrin Receptor Signaling Pathway Membrane Organization Actin Polymerization-dependent Cell Motility Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Actin Nucleation Ephrin Receptor Signaling Pathway Membrane Organization
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one	N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Inflammatory bowel disease ( 28067908 23128233) Mean platelet volume ( 32888494 27863252) Neutrophil count ( 29403010) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) White blood cell count ( 25096241 29403010)
Interacting Genes		6 interacting genes: ACTR3 ARPC1B ARPC4 AURKA CORO1B WAS	13 interacting genes: ACTR2 ACTR3 ARPC1B ARPC2 ARPC3 ARPC5 ARPC5L CLK1 METTL21A NELFCD PNMA5 RNF130 WASL
Entrez ID		10109	10093
HPRD ID		10367	10368
Ensembl ID		ENSG00000163466	ENSG00000241553
Uniprot IDs		A0A024R408 O15144 Q53R19	P59998
PDB IDs		6UHC 6YW6 6YW7	6UHC 6YW6 6YW7
Enriched GO Terms of Interacting Partners?
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