ARPC4 and RNF130

Data Source:
HPRD (two hybrid)

		ARPC4	RNF130
Description		actin related protein 2/3 complex subunit 4	ring finger protein 130
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Arp2/3 Protein Complex Site Of Double-strand Break Cell Projection Extracellular Exosome	Cytoplasm Integral Component Of Membrane
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Actin Filament Binding	Ubiquitin-protein Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Actin Nucleation Ephrin Receptor Signaling Pathway Membrane Organization	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Programmed Cell Death Protein Ubiquitination
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS			LDL cholesterol ( 21347282) Pre-treatment viral load in HIV-1 infection ( 31219150) Systolic blood pressure ( 30224653)
Interacting Genes		13 interacting genes: ACTR2 ACTR3 ARPC1B ARPC2 ARPC3 ARPC5 ARPC5L CLK1 METTL21A NELFCD PNMA5 RNF130 WASL	13 interacting genes: ARPC4 FGFR3 SCN2A TGFBR1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2Z
Entrez ID		10093	55819
HPRD ID		10368	11504
Ensembl ID		ENSG00000241553	ENSG00000113269
Uniprot IDs		P59998	E5RI87 Q2HIY3 Q86XS8
PDB IDs		6UHC 6YW6 6YW7
Enriched GO Terms of Interacting Partners?
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