ACTR2 and ARPC1B

Data Source:
BioGRID (proximity labelling technology, affinity chromatography technology, proximity labelling technology)
HPRD (in vitro, in vivo)

		ACTR2	ARPC1B
Description		actin related protein 2	actin related protein 2/3 complex subunit 1B
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Arp2/3 Protein Complex Focal Adhesion Postsynaptic Density Actin Cytoskeleton Membrane Lamellipodium Actin Cap Azurophil Granule Lumen Site Of Double-strand Break Podosome Core Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Tubulobulbar Complex Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Actin Filament Binding	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding
	Biological Process	Establishment Or Maintenance Of Cell Polarity Associative Learning Asymmetric Cell Division Positive Regulation Of Lamellipodium Assembly Meiotic Chromosome Movement Towards Spindle Pole Cytosolic Transport Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Response To Immobilization Stress Cellular Response To Trichostatin A Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neutrophil Degranulation Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Spindle Localization Cilium Assembly Positive Regulation Of Dendritic Spine Morphogenesis Membrane Organization Cellular Response To Interferon-gamma Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Response To Estradiol Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Estrogen Ephrin Receptor Signaling Pathway
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one	N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Calcific aortic valve stenosis ( 32141789) Coronary artery disease ( 29212778 33020668) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Metabolite levels ( 23823483)	Alcohol consumption ( 31358974) Facial emotion recognition (sad faces) ( 28608620) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum metabolite levels ( 23093944)
Interacting Genes		14 interacting genes: ACTC1 ACTR3 ARPC1B ARPC4 ARPC5 BMP2 ELF5 ERCC6 HCLS1 IQGAP2 SHARPIN WASF1 WASF2 WASL	10 interacting genes: ACTB ACTR2 APP ARPC2 ARPC4 ARPC5 AURKA PAK1 SRPK2 WAS
Entrez ID		10097	10095
HPRD ID		05023	10366
Ensembl ID		ENSG00000138071	ENSG00000130429
Uniprot IDs		P61160	A4D275 O15143
PDB IDs		6UHC 6YW6 6YW7	6UHC 6YW6
Enriched GO Terms of Interacting Partners?
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