ARPC1B and ARPC4

Data Source:
HPRD (in vitro)

		ARPC1B	ARPC4
Description		actin related protein 2/3 complex subunit 1B	actin related protein 2/3 complex subunit 4
Image
GO Annotations	Cellular Component	Nucleus Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Tubulobulbar Complex Extracellular Exosome	Nucleus Cytosol Arp2/3 Protein Complex Site Of Double-strand Break Cell Projection Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	Structural Constituent Of Cytoskeleton Protein Binding Enzyme Binding Protein-macromolecule Adaptor Activity Actin Filament Binding
	Biological Process	Response To Estradiol Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Estrogen Ephrin Receptor Signaling Pathway	Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Actin Nucleation Ephrin Receptor Signaling Pathway Membrane Organization
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one	N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Alcohol consumption ( 31358974) Facial emotion recognition (sad faces) ( 28608620) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum metabolite levels ( 23093944)
Interacting Genes		10 interacting genes: ACTB ACTR2 APP ARPC2 ARPC4 ARPC5 AURKA PAK1 SRPK2 WAS	13 interacting genes: ACTR2 ACTR3 ARPC1B ARPC2 ARPC3 ARPC5 ARPC5L CLK1 METTL21A NELFCD PNMA5 RNF130 WASL
Entrez ID		10095	10093
HPRD ID		10366	10368
Ensembl ID		ENSG00000130429	ENSG00000241553
Uniprot IDs		A4D275 O15143	P59998
PDB IDs		6UHC 6YW6	6UHC 6YW6 6YW7
Enriched GO Terms of Interacting Partners?
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