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RNF130 and FGFR3
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
RNF130
FGFR3
Description
ring finger protein 130
fibroblast growth factor receptor 3
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Integral Component Of Membrane
Extracellular Region
Nucleus
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Cell Surface
Transport Vesicle
Receptor Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Fibroblast Growth Factor-activated Receptor Activity
Protein Binding
ATP Binding
Fibroblast Growth Factor Binding
Identical Protein Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Programmed Cell Death
Protein Ubiquitination
MAPK Cascade
Skeletal System Development
Endochondral Ossification
Chondrocyte Differentiation
Endochondral Bone Growth
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cell-cell Signaling
Multicellular Organism Development
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phospholipase Activity
Peptidyl-tyrosine Phosphorylation
Bone Mineralization
Positive Regulation Of Kinase Activity
Chondrocyte Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of MAPK Cascade
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Protein Autophosphorylation
Negative Regulation Of Developmental Growth
Positive Regulation Of Protein Kinase B Signaling
Bone Morphogenesis
Positive Regulation Of ERK1 And ERK2 Cascade
Bone Maturation
Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Signaling by activated point mutants of FGFR3
FGFR3 mutant receptor activation
t(4;14) translocations of FGFR3
Signaling by FGFR3 fusions in cancer
Signaling by FGFR3 point mutants in cancer
Drugs
XL999
Pazopanib
Ponatinib
Lenvatinib
Nintedanib
Fostamatinib
Erdafitinib
Pemigatinib
Selpercatinib
Diseases
Bladder cancer
Multiple myeloma
Lacrimo-auriculo-dento-digital syndrome (LADD); Levy-Hollister syndrome
Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
FGFR3-related short limb skeletal dysplasias, including: Achondroplasia; Hypochondroplasia; Thanatophoric dysplasia, type 1; Thanatophoric dysplasia, type 2; Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN)
CATSHL syndrome
GWAS
LDL cholesterol (
21347282
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Systolic blood pressure (
30224653
)
Bladder cancer (
24163127
20972438
)
Blood protein levels (
30072576
)
Metabolite levels (
23823483
)
Urinary bladder cancer (
20348956
)
Interacting Genes
13 interacting genes:
ARPC4
FGFR3
SCN2A
TGFBR1
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E3
UBE2N
UBE2Z
43 interacting genes:
ANOS1
ARAP1
ATF3
BORA
C6orf47
CCDC17
CEP126
CHGB
CTSK
EPHA4
ERBB2
FGF1
FGF17
FGF18
FGF2
FGF23
FGF3
FGF4
FGF5
FGF6
FGF7
FGF8
FGF9
GPSM3
GRB2
GTF3C1
HBZ
HNRNPL
KRT8
NDUFS6
NECTIN1
POLA2
PTK2B
RADIL
RNF130
RPL8
RPS6KA3
SH2B1
SLC25A6
SMG7
SRPK2
STAT1
STAT3
Entrez ID
55819
2261
HPRD ID
11504
00624
Ensembl ID
ENSG00000113269
ENSG00000068078
Uniprot IDs
E5RI87
Q2HIY3
Q86XS8
P22607
Q0IJ44
PDB IDs
1RY7
2LZL
4K33
6LVM
6PNX
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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