SMC4 and SMC2

Data Source:
HPRD (in vitro, in vivo)

		SMC4	SMC2
Description		structural maintenance of chromosomes 4	structural maintenance of chromosomes 2
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensin Complex Nucleus Nucleoplasm Cytosol Nuclear Speck	Nuclear Chromosome Condensed Chromosome Condensin Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding	Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Chromosome Condensation Meiotic Chromosome Condensation Meiotic Chromosome Segregation Cell Division Kinetochore Organization	Mitotic Chromosome Condensation Meiotic Chromosome Condensation Meiotic Chromosome Segregation Cell Division Kinetochore Organization
Pathways		Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes	Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes
Drugs
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 31043756) Malaria ( 31844061)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Apolipoprotein A1 levels ( 32203549) Basal cell carcinoma ( 31174203) HDL cholesterol levels ( 32203549) Keratinocyte cancer (MTAG) ( 31174203) Oily fish consumption ( 32066663) Orofacial clefts (maternal alcohol consumption interaction) ( 21618603) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Pork consumption ( 32066663) Sensorimotor dexterity ( 31596458)
Interacting Genes		5 interacting genes: NCAPD2 PTEN SMC2 SUMO2 TRAF3IP1	11 interacting genes: ABCC5 CDC42 DISC1 DNMT3B GULP1 LIG4 NCAPD2 PTEN SMC4 SUMO2 TRAF3IP1
Entrez ID		10051	10592
HPRD ID		09276	09277
Ensembl ID		ENSG00000113810	ENSG00000136824
Uniprot IDs		B3KXX5 E9PD53 Q58F29 Q9NTJ3	A0A024R158 A8K984 B3KMB1 B7ZLZ7 O95347 Q05BV1 Q05D74 Q6IPS5 Q7Z2X1
PDB IDs		4U4P	4U4P
Enriched GO Terms of Interacting Partners?
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