SMC2 and ABCC5

Data Source:
BioGRID (two hybrid)

		SMC2	ABCC5
Description		structural maintenance of chromosomes 2	ATP binding cassette subfamily C member 5
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Condensed Chromosome Condensin Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Extracellular Exosome	Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane
	Molecular Function	Chromatin Binding Single-stranded DNA Binding Protein Binding ATP Binding	ATP Binding Organic Anion Transmembrane Transporter Activity Purine Nucleotide Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity ATPase Activity Glutathione Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity
	Biological Process	Mitotic Chromosome Condensation Meiotic Chromosome Condensation Meiotic Chromosome Segregation Cell Division Kinetochore Organization	Purine Nucleotide Transport Hyaluronan Biosynthetic Process Glutathione Transmembrane Transport Xenobiotic Transport Transmembrane Transport Export Across Plasma Membrane Transport Across Blood-brain Barrier
Pathways		Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes	Hyaluronan biosynthesis and export ABC-family proteins mediated transport
Drugs			Curcumin Curcumin sulfate
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Apolipoprotein A1 levels ( 32203549) Basal cell carcinoma ( 31174203) HDL cholesterol levels ( 32203549) Keratinocyte cancer (MTAG) ( 31174203) Oily fish consumption ( 32066663) Orofacial clefts (maternal alcohol consumption interaction) ( 21618603) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Pork consumption ( 32066663) Sensorimotor dexterity ( 31596458)	Anterior chamber depth ( 24603532) Basophil percentage of white cells ( 32888494) Eosinophil counts ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Type 2 diabetes ( 30297969) White blood cell count ( 32888494)
Interacting Genes		11 interacting genes: ABCC5 CDC42 DISC1 DNMT3B GULP1 LIG4 NCAPD2 PTEN SMC4 SUMO2 TRAF3IP1	4 interacting genes: AK2 RBP5 SERPINA3 SMC2
Entrez ID		10592	10057
HPRD ID		09277	06898
Ensembl ID		ENSG00000136824	ENSG00000114770
Uniprot IDs		A0A024R158 A8K984 B3KMB1 B7ZLZ7 O95347 Q05BV1 Q05D74 Q6IPS5 Q7Z2X1	O15440
PDB IDs		4U4P
Enriched GO Terms of Interacting Partners?
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