HMGXB4 and UROD

Data Source:
BioGRID (two hybrid)

		HMGXB4	UROD
Description		HMG-box containing 4	uroporphyrinogen decarboxylase
Image		No pdb structure
GO Annotations	Cellular Component	NURF Complex	Nucleoplasm Cytosol
	Molecular Function	DNA Binding Protein Binding Identical Protein Binding	Uroporphyrinogen Decarboxylase Activity Protein Binding
	Biological Process	Endosome To Lysosome Transport Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway	Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process
Pathways			Heme biosynthesis
Drugs			Coproporphyrin I Coproporphyrinogen III
Diseases			Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)
GWAS		Hip circumference adjusted for BMI ( 25673412) Platelet count ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		24 interacting genes: AKAP17A CREBBP EPM2A H3-4 HABP4 INO80B JMJD6 LENG8 MX1 NKAPD1 NR1H2 PIAS2 SRPK2 STAC3 STRBP SUMO2 TENT5B TNNT1 TSC22D1 TSPYL2 UBE2I UBL5 UROD ZCCHC10	10 interacting genes: CHD3 EGFR FAF1 FBXO7 HMGXB4 LRATD2 PHKA2 PILRA TSSK3 VIM
Entrez ID		10042	7389
HPRD ID		05267	01441
Ensembl ID		ENSG00000100281	ENSG00000126088
Uniprot IDs		Q7Z641 Q9UGU5	P06132
PDB IDs			1JPH 1JPI 1JPK 1R3Q 1R3R 1R3S 1R3T 1R3V 1R3W 1R3Y 1URO 2Q6Z 2Q71 3GVQ 3GVR 3GVV 3GVW 3GW0 3GW3
Enriched GO Terms of Interacting Partners?
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