TBC1D1 and L3MBTL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TBC1D1	L3MBTL3
Description		TBC1 domain family member 1	L3MBTL histone methyl-lysine binding protein 3
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GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Nucleolus
	Molecular Function	GTPase Activator Activity Protein Binding	Molecular_function Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding
	Biological Process	Intracellular Protein Transport Regulation Of Protein Localization Activation Of GTPase Activity Regulation Of Cilium Assembly	Chromatin Organization Macrophage Differentiation Granulocyte Differentiation Erythrocyte Maturation Negative Regulation Of Transcription, DNA-templated
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Amyotrophic lateral sclerosis in C9orf72 mutation negative individuals ( 22959728) Bipolar disorder ( 34099189) Crohn's disease ( 23850713 23266558) Diastolic blood pressure ( 27841878 27618452) Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821) High-sensitivity cardiac troponin T levels ( 33321125) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Periodontal microbiota ( 22699663) Pulse pressure ( 27841878) Response to antidepressants (symptom remission) ( 29160301) Response to SSRI (symptom remission) ( 29160301) Systolic blood pressure ( 27841878 27618452) Verbal declarative memory ( 25648963) Weight ( 28552196) White blood cell count ( 32888494)	Alanine aminotransferase levels ( 33547301 34315874) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301 34315874) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Birth weight ( 31043758 27680694) Body mass index ( 25673413) Body shape index ( 34021172) Breast cancer ( 29059683 29058716) Breast cancer (estrogen-receptor negative) ( 29058716) C-reactive protein levels ( 30388399) Chronic kidney disease ( 31152163) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 20881960 25282103 25429064 23563607 31562340 18391951) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 28552196 34021172 25673412) Immature fraction of reticulocytes ( 32888494) Influenza A (H1N1) infection ( 26379185) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte counts ( 32888494 27863252) Mild influenza (H1N1) infection ( 26379185) Multiple sclerosis ( 31604244 27386562) Offspring birth weight ( 31043758) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Spleen volume ( 34128465) Triglyceride levels ( 32203549 32154731) Triglyceride levels in HIV infection ( 33109212) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		31 interacting genes: CALM1 CALM2 CALM3 CCDC185 CWF19L2 EFHC2 FAM161A FAM50B GABARAPL1 GMCL1 HOXC8 HSF2BP HSPB1 KRT75 L3MBTL3 LHX8 LNX1 LZTS1 MAP1LC3A MCRS1 PNKP RIN1 SMAD2 SYTL4 TCEA2 TNNC2 TSGA10IP TXLNA VPS52 YWHAG ZFP1	57 interacting genes: ASB6 BANP BYSL C1QTNF4 CRLF3 DEF6 DNMT1 FLAD1 FNDC3B FXR2 GAS8 H3C1 HSF2BP IL16 KANK2 KDM1A LIG1 LMO4 LRRK2 LSM4 LZTR1 MAPK3 MAPK9 MFAP1 MORF4L1 MORF4L2 NGB NRF1 NTAQ1 OAZ3 PDE6G PHC2 PHF21A PIK3R3 PLEKHF1 PLEKHF2 PLOD3 POLR2L PPP2CA PRKAA1 PRKAA2 RHOBTB3 SFMBT2 SNRPB SOX2 SP100 SPANXN2 SUFU SUMO1P1 TBC1D1 TCEANC THRA TRAF3IP3 TSTD2 TTC19 ZCWPW1 ZNF76
Entrez ID		23216	84456
HPRD ID		18161	11222
Ensembl ID		ENSG00000065882	ENSG00000198945
Uniprot IDs		B9A6J6 Q6PJJ8 Q86TI0 Q8NC59	Q96JM7
PDB IDs		3QYE	1WJQ 1WJS 3UT1 4FL6 4L59
Enriched GO Terms of Interacting Partners?
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