CPNE1 and TRPC4AP

		CPNE1	TRPC4AP
Description		copine 1	transient receptor potential cation channel subfamily C member 4 associated protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Membrane Azurophil Granule Membrane Extracellular Exosome	Plasma Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Phosphatidylserine Binding Endopeptidase Activity Transporter Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Identical Protein Binding NF-kappaB Binding	Calcium Channel Activity Protein Binding Phosphatase Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	Proteolysis Lipid Metabolic Process Negative Regulation Of Gene Expression Vesicle-mediated Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA Binding Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Calcium Ion Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Neuron Projection Extension	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Hair Follicle Maturation Calcium Ion Transmembrane Transport Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway
Pathways		Glycerophospholipid biosynthesis Neutrophil degranulation	TRP channels
Drugs		Theophylline
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Basal cell carcinoma ( 33549134) Blood protein levels ( 28240269) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Prothrombin time ( 22703881) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		21 interacting genes: ACTB BCOR BUB3 CCDC22 CPNE4 LHX6 LIG4 MAP2K1 MYCBP PDCD6 PITPNM2 PPP5C RDX SKIL SORBS3 SPTBN1 STK3 TRPC4AP UBE2M UBE2O WTAP	18 interacting genes: CHMP4C CHUK CPNE1 CUL4B EDEM2 IKBKB IKBKG MED26 MTDH PCDH11X PGLYRP4 RIPK1 TAB1 TNFRSF1A TRADD TRAF2 UQCC1 VMP1
Entrez ID		8904	26133
HPRD ID		05014	09238
Ensembl ID		ENSG00000214078	ENSG00000100991
Uniprot IDs		B0QZ18 Q99829	B4DW48 Q8TEL6
PDB IDs
Enriched GO Terms of Interacting Partners?
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