CPNE1 and PITPNM2

Number of citations of the paper that reports this interaction (PubMedID 12522145)
38

Data Source:
HPRD (in vitro)

		CPNE1	PITPNM2
Description		copine 1	phosphatidylinositol transfer protein membrane associated 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Membrane Azurophil Granule Membrane Extracellular Exosome	Cytoplasm Cytosol Endomembrane System Membrane Cell Body
	Molecular Function	Phosphatidylserine Binding Endopeptidase Activity Transporter Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Identical Protein Binding NF-kappaB Binding	Calcium Ion Binding Phosphatidylcholine Transporter Activity Phosphatidylinositol Transfer Activity Receptor Tyrosine Kinase Binding Phosphatidylcholine Binding Phosphatidylinositol Binding
	Biological Process	Proteolysis Lipid Metabolic Process Negative Regulation Of Gene Expression Vesicle-mediated Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of DNA Binding Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Calcium Ion Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Neuron Projection Extension	Phosphatidylinositol Biosynthetic Process Phospholipid Transport Phosphatidylinositol-mediated Signaling Intermembrane Lipid Transfer
Pathways		Glycerophospholipid biosynthesis Neutrophil degranulation	Synthesis of PI
Drugs		Theophylline
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 32296059) Asthma (childhood onset) ( 30929738) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body shape index ( 34021172) Brain morphology (MOSTest) ( 32665545) Educational attainment ( 25201988) Eosinophil percentage of white cells ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172 25673412) Hip index ( 34021172) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Macular thickness ( 30535121) Mean platelet volume ( 27863252) Menopause (age at onset) ( 26414677) Multiple sclerosis ( 31604244 24076602) Platelet count ( 21507922) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 28991256 25056061 29483656 23974872) Tourette syndrome ( 30818990) Type 2 diabetes ( 30054458) Uterine fibroids ( 31649266) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		21 interacting genes: ACTB BCOR BUB3 CCDC22 CPNE4 LHX6 LIG4 MAP2K1 MYCBP PDCD6 PITPNM2 PPP5C RDX SKIL SORBS3 SPTBN1 STK3 TRPC4AP UBE2M UBE2O WTAP	3 interacting genes: CPNE1 CPNE4 PTK2B
Entrez ID		8904	57605
HPRD ID		05014	08335
Ensembl ID		ENSG00000214078	ENSG00000090975
Uniprot IDs		B0QZ18 Q99829	Q9BZ72 Q9UF51
PDB IDs
Enriched GO Terms of Interacting Partners?
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