TRPC4AP and RIPK1

Number of citations of the paper that reports this interaction (PubMedID 14585990)
10

Data Source:
HPRD (in vitro, in vivo)

		TRPC4AP	RIPK1
Description		transient receptor potential cation channel subfamily C member 4 associated protein	receptor interacting serine/threonine kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex	Mitochondrion Cytosol Plasma Membrane Endosome Membrane Death-inducing Signaling Complex Protein-containing Complex Receptor Complex Membrane Raft Ripoptosome
	Molecular Function	Calcium Channel Activity Protein Binding Phosphatase Binding Ubiquitin Ligase-substrate Adaptor Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity Death Receptor Binding Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Death Domain Binding Protein Serine Kinase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Hair Follicle Maturation Calcium Ion Transmembrane Transport Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway	Positive Regulation Of Protein Phosphorylation Apoptotic Process Inflammatory Response Cell Death Positive Regulation Of Necrotic Cell Death Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Response To Tumor Necrosis Factor Peptidyl-serine Autophosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Protein Catabolic Process Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Protein Autophosphorylation Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Positive Regulation Of Interleukin-6-mediated Signaling Pathway T Cell Apoptotic Process Necroptotic Process Cellular Response To Hydrogen Peroxide Regulation Of ATP:ADP Antiporter Activity Cellular Response To Tumor Necrosis Factor Extrinsic Apoptotic Signaling Pathway Programmed Necrotic Cell Death Ripoptosome Assembly Necroptotic Signaling Pathway Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of Hydrogen Peroxide-induced Cell Death Amyloid Fibril Formation Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		TRP channels	Caspase activation via Death Receptors in the presence of ligand TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Regulation of necroptotic cell death Ub-specific processing proteases Ovarian tumor domain proteases Dimerization of procaspase-8 TNF signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IKK complex recruitment mediated by RIP1 Potential therapeutics for SARS Microbial modulation of RIPK1-mediated regulated necrosis Defective RIPK1-mediated regulated necrosis
Drugs			Fostamatinib
Diseases
GWAS		Basal cell carcinoma ( 33549134) Blood protein levels ( 28240269) Fish- and plant-related diet ( 32066663) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Prothrombin time ( 22703881) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Cerebral white matter volume ( 31530798) Depressive symptoms x independent stressful life events interaction (1df test) ( 30718454) Depressive symptoms x independent stressful life events interaction (2df test) ( 30718454) Idiopathic osteonecrosis of the femoral head ( 28000841)
Interacting Genes		18 interacting genes: CHMP4C CHUK CPNE1 CUL4B EDEM2 IKBKB IKBKG MED26 MTDH PCDH11X PGLYRP4 RIPK1 TAB1 TNFRSF1A TRADD TRAF2 UQCC1 VMP1	52 interacting genes: BIRC3 CASP8 CCDC50 CDC42BPB CFLAR CRADD EGFR FADD FAS GMPR H2BC13 HSP90AA1 IKBKB IKBKE IKBKG ITCH MAP3K1 MAP3K14 MAP3K3 MAP3K8 MTDH NFKB1 NUMBL OTUD1 PDXK PRPF4B PTK2 PXDC1 RIPK3 RNF11 RNF216 SQSTM1 TAX1BP1 TBK1 TICAM1 TNF TNFAIP3 TNFRSF10A TNFRSF10B TNFRSF1A TRADD TRAF1 TRAF2 TRAF3 TRAF5 TRIM38 TRPC4AP UBE2N WRNIP1 YOD1 ZFAND5 ZNHIT1
Entrez ID		26133	8737
HPRD ID		09238	04583
Ensembl ID		ENSG00000100991	ENSG00000137275
Uniprot IDs		B4DW48 Q8TEL6	A0A024QZU0 Q13546
PDB IDs			4ITH 4ITI 4ITJ 4NEU 5HX6 5TX5 5V7Z 6AC5 6C3E 6C4D 6HHO 6NW2 6NYH 6OCQ 6R5F 6RLN
Enriched GO Terms of Interacting Partners?
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