SYVN1 and USP15

Number of citations of the paper that reports this interaction (PubMedID 31477895)
5

Data Source:
BioGRID (pull down, affinity chromatography technology)

		SYVN1	USP15
Description		synoviolin 1	ubiquitin specific peptidase 15
Image
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Hrd1p Ubiquitin Ligase ERAD-L Complex Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane
	Molecular Function	Protein Binding Metal Ion Binding Unfolded Protein Binding Chaperone Binding ATPase Binding Ubiquitin Protein Ligase Activity Ubiquitin-specific Protease Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Transforming Growth Factor Beta Receptor Binding Protein Binding Identical Protein Binding SMAD Binding Ubiquitin Modification-dependent Histone Binding Lys48-specific Deubiquitinase Activity
	Biological Process	Immature B Cell Differentiation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol ERAD Pathway Protein Stabilization Protein K48-linked Ubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Mannose Trimming	Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein Deubiquitination BMP Signaling Pathway Monoubiquitinated Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Pathway-restricted SMAD Protein Phosphorylation Protein K48-linked Deubiquitination Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Antifungal Innate Immune Response Protein K27-linked Deubiquitination
Pathways		XBP1(S) activates chaperone genes Hedgehog ligand biogenesis Hh mutants are degraded by ERAD ER Quality Control Compartment (ERQC)	Downregulation of TGF-beta receptor signaling UCH proteinases Ub-specific processing proteases
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Crohn's disease ( 32581322)	Alopecia areata ( 25608926) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Pulmonary function decline ( 22424883) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)
Interacting Genes		14 interacting genes: APP ATL1 ATN1 CLU ERN1 GPR37 TP53 UBE2D2 UBE2D3 UBE2G1 UBE2U UBE2Z USP15 USP7	55 interacting genes: BAP1 BMI1 BMPR1A BRAP CARD9 CCDC57 CDK4 DDX58 FHL1 GEMIN4 GOLGA2 GOLGA6A H2BC21 IL1R2 JOSD1 KEAP1 MAD1L1 MDC1 MDM2 OTUB1 PHF7 PIBF1 PLA2G2A PRPF31 RBCK1 RNF126 RNF144B SENP3 SENP8 SMURF2 SPDL1 STAM STK33 SYVN1 TEX11 TRAF6 TRIM17 TRIM21 TRIM25 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 UCHL1 UCHL3 USP14 USP2 USP20 USP21 USP28 USP33 USP51 USP8 YOD1
Entrez ID		84447	9958
HPRD ID		07618	05293
Ensembl ID		ENSG00000162298	ENSG00000135655
Uniprot IDs		Q86TM6	Q9Y4E8
PDB IDs		6A3Z	1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P 5JJW 6CPM 6CRN 6DJ9 6GH9 6GHA 6ML1
Enriched GO Terms of Interacting Partners?
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