SYVN1 and ERN1

Number of citations of the paper that reports this interaction (PubMedID 18369366)
48

Data Source:
HPRD (in vivo)

		SYVN1	ERN1
Description		synoviolin 1	endoplasmic reticulum to nucleus signaling 1
Image
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Hrd1p Ubiquitin Ligase ERAD-L Complex Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment	Nuclear Inner Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Ire1 Complex AIP1-IRE1 Complex IRE1-TRAF2-ASK1 Complex IRE1-RACK1-PP2A Complex
	Molecular Function	Protein Binding Metal Ion Binding Unfolded Protein Binding Chaperone Binding ATPase Binding Ubiquitin Protein Ligase Activity Ubiquitin-specific Protease Binding	Magnesium Ion Binding Endoribonuclease Activity Protein Serine/threonine Kinase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Enzyme Binding Hsp70 Protein Binding Identical Protein Binding Protein Homodimerization Activity ADP Binding Unfolded Protein Binding Hsp90 Protein Binding Protein Serine Kinase Activity
	Biological Process	Immature B Cell Differentiation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol ERAD Pathway Protein Stabilization Protein K48-linked Ubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Mannose Trimming	Endothelial Cell Proliferation MRNA Cleavage MRNA Catabolic Process Protein Phosphorylation Regulation Of Macroautophagy Positive Regulation Of RNA Splicing Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Cellular Response To Vascular Endothelial Growth Factor Stimulus Peptidyl-serine Autophosphorylation IRE1-mediated Unfolded Protein Response Positive Regulation Of JUN Kinase Activity Protein Autophosphorylation Regulation Of Cell Cycle MRNA Splicing, Via Endonucleolytic Cleavage And Ligation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Glucose Stimulus RNA Phosphodiester Bond Hydrolysis, Endonucleolytic MRNA Cleavage Involved In MRNA Processing Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Insulin Metabolic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Peptidyl-serine Trans-autophosphorylation
Pathways		XBP1(S) activates chaperone genes Hedgehog ligand biogenesis Hh mutants are degraded by ERAD ER Quality Control Compartment (ERQC)	IRE1alpha activates chaperones IRE1alpha activates chaperones
Drugs			N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine Fostamatinib
Diseases
GWAS		Blood protein levels ( 28240269) Crohn's disease ( 32581322)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver injury in anti-retroviral drug treated HIV ( 28388302)
Interacting Genes		14 interacting genes: APP ATL1 ATN1 CLU ERN1 GPR37 TP53 UBE2D2 UBE2D3 UBE2G1 UBE2U UBE2Z USP15 USP7	15 interacting genes: BAK1 BAX CEP112 COPS5 HSP90AA1 HSPA5 MAP3K5 P4HB PSEN1 SRPK2 STUB1 SYVN1 TAOK3 TNFRSF1A TRAF2
Entrez ID		84447	2081
HPRD ID		07618	04943
Ensembl ID		ENSG00000162298	ENSG00000178607
Uniprot IDs		Q86TM6	O75460
PDB IDs		6A3Z	2HZ6 3P23 4U6R 4YZ9 4YZC 4YZD 4Z7G 4Z7H 5HGI 6HV0 6HX1 6SHC 6URC 6W39 6W3A 6W3B 6W3C 6W3E 6W3K
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?