USP15 and UCHL1

Number of citations of the paper that reports this interaction (PubMedID 22626734)
6

Data Source:
BioGRID (enzymatic study)

		USP15	UCHL1
Description		ubiquitin specific peptidase 15	ubiquitin C-terminal hydrolase L1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane	Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Neuronal Cell Body Neuron Projection Terminus Axon Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Transforming Growth Factor Beta Receptor Binding Protein Binding Identical Protein Binding SMAD Binding Ubiquitin Modification-dependent Histone Binding Lys48-specific Deubiquitinase Activity	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Omega Peptidase Activity Ligase Activity Ubiquitin Protein Ligase Binding Alpha-2A Adrenergic Receptor Binding Ubiquitin Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein Deubiquitination BMP Signaling Pathway Monoubiquitinated Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Pathway-restricted SMAD Protein Phosphorylation Protein K48-linked Deubiquitination Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Antifungal Innate Immune Response Protein K27-linked Deubiquitination	Response To Ischemia Axon Target Recognition Adult Walking Behavior Cell Population Proliferation Regulation Of Macroautophagy Protein Deubiquitination Sensory Perception Of Pain Axonal Transport Of Mitochondrion Eating Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Neuromuscular Process Muscle Cell Development Cellular Response To Xenobiotic Stimulus
Pathways		Downregulation of TGF-beta receptor signaling UCH proteinases Ub-specific processing proteases	UCH proteinases
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Alopecia areata ( 25608926) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Pulmonary function decline ( 22424883) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)	Cognitive performance ( 19734545) Metabolite levels ( 23823483)
Interacting Genes		55 interacting genes: BAP1 BMI1 BMPR1A BRAP CARD9 CCDC57 CDK4 DDX58 FHL1 GEMIN4 GOLGA2 GOLGA6A H2BC21 IL1R2 JOSD1 KEAP1 MAD1L1 MDC1 MDM2 OTUB1 PHF7 PIBF1 PLA2G2A PRPF31 RBCK1 RNF126 RNF144B SENP3 SENP8 SMURF2 SPDL1 STAM STK33 SYVN1 TEX11 TRAF6 TRIM17 TRIM21 TRIM25 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 UCHL1 UCHL3 USP14 USP2 USP20 USP21 USP28 USP33 USP51 USP8 YOD1	28 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 AKT1 CBX1 CDKN1B COPS5 HSP90AA1 HSPA8 LAMP2 MYCBP2 NCAM1 NEDD8 PLA2G2A RANBP9 SHANK3 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBC UBE2I USP15 USP21 USP28
Entrez ID		9958	7345
HPRD ID		05293	01877
Ensembl ID		ENSG00000135655	ENSG00000154277
Uniprot IDs		Q9Y4E8	P09936 V9HW74
PDB IDs		1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P 5JJW 6CPM 6CRN 6DJ9 6GH9 6GHA 6ML1	2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9 4JKJ
Enriched GO Terms of Interacting Partners?
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