ERN1 and MAP3K5

Number of citations of the paper that reports this interaction (PubMedID 12050113)
438

Data Source:
BioGRID (imaging technique, affinity chromatography technology)
HPRD (in vivo)

		ERN1	MAP3K5
Description		endoplasmic reticulum to nucleus signaling 1	mitogen-activated protein kinase kinase kinase 5
Image
GO Annotations	Cellular Component	Nuclear Inner Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Ire1 Complex AIP1-IRE1 Complex IRE1-TRAF2-ASK1 Complex IRE1-RACK1-PP2A Complex	Cytoplasm Cytosol External Side Of Plasma Membrane Protein-containing Complex Protein Kinase Complex IRE1-TRAF2-ASK1 Complex
	Molecular Function	Magnesium Ion Binding Endoribonuclease Activity Protein Serine/threonine Kinase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Enzyme Binding Hsp70 Protein Binding Identical Protein Binding Protein Homodimerization Activity ADP Binding Unfolded Protein Binding Hsp90 Protein Binding Protein Serine Kinase Activity	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity
	Biological Process	Endothelial Cell Proliferation MRNA Cleavage MRNA Catabolic Process Protein Phosphorylation Regulation Of Macroautophagy Positive Regulation Of RNA Splicing Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Cellular Response To Vascular Endothelial Growth Factor Stimulus Peptidyl-serine Autophosphorylation IRE1-mediated Unfolded Protein Response Positive Regulation Of JUN Kinase Activity Protein Autophosphorylation Regulation Of Cell Cycle MRNA Splicing, Via Endonucleolytic Cleavage And Ligation Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Glucose Stimulus RNA Phosphodiester Bond Hydrolysis, Endonucleolytic MRNA Cleavage Involved In MRNA Processing Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Insulin Metabolic Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Peptidyl-serine Trans-autophosphorylation	MAPK Cascade Response To Ischemia Protein Phosphorylation JNK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Stress Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress Wound Healing Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of JUN Kinase Activity Innate Immune Response Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Stress-activated MAPK Cascade Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Endothelial Cell Apoptotic Process Cellular Senescence Apoptotic Signaling Pathway Positive Regulation Of P38MAPK Cascade Positive Regulation Of Neuron Death Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		IRE1alpha activates chaperones IRE1alpha activates chaperones	Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence
Drugs		N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine Fostamatinib
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver injury in anti-retroviral drug treated HIV ( 28388302)	Eosinophil counts ( 32888494) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		15 interacting genes: BAK1 BAX CEP112 COPS5 HSP90AA1 HSPA5 MAP3K5 P4HB PSEN1 SRPK2 STUB1 SYVN1 TAOK3 TNFRSF1A TRAF2	65 interacting genes: AKT1 ARRB2 AURKA CCND2 CDC25A CDK4 CDK6 CDKN1A CDKN2A CREBBP DAB2IP DAXX DMD DUSP19 EIF2AK2 EP300 ERN1 FGFR4 FZR1 GADD45B GEMIN5 GLIS2 GLRX GSTM1 HSPA1A IGF1R JAK2 KIAA0408 MAP2K4 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K6 MAP3K7 MAPK8IP3 MBP NEDD4 NEDD4L NF2 PDCD6 PPP3R1 PPP5C PTPN11 QARS1 RAF1 SFN SIAH1 STK11 TEAD2 TERT TNFAIP3 TNNT2 TPD52L1 TRAF2 TRAF5 TRAF6 TULP3 TXN UBE2I USP9X YWHAE YWHAH YWHAQ YWHAZ
Entrez ID		2081	4217
HPRD ID		04943	03904
Ensembl ID		ENSG00000178607	ENSG00000197442
Uniprot IDs		O75460	Q99683
PDB IDs		2HZ6 3P23 4U6R 4YZ9 4YZC 4YZD 4Z7G 4Z7H 5HGI 6HV0 6HX1 6SHC 6URC 6W39 6W3A 6W3B 6W3C 6W3E 6W3K	2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE 5ULM 5UOR 5UOX 5UP3 5V19 5V24 5VIL 5VIO 6E2M 6E2N 6E2O 6EJL 6OYT 6OYW 6VRE 6XIH
Enriched GO Terms of Interacting Partners?
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